Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLG | P00747 | 13/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 1/20 | 0.36 |
| ▸ | GABRG2 | P18507 | 1/20 | 0.36 |
| ▸ | GABRB3 | P28472 | 1/20 | 0.36 |
| ▸ | OPRM1 | P35372 | 1/20 | 0.31 |
| ▸ | OPRD1 | P41143 | 1/20 | 0.31 |
| ▸ | SIGMAR1 | Q99720 | 1/20 | 0.31 |
| ▸ | TACR1 | P25103 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27965648 | 1.00 | PLG (0.48) | PLGGABRA1GABRG2GABRB3OPRM1 | |
| SCHEMBL582134 | 1.00 | PLG (0.48) | PLGGABRA1GABRG2GABRB3OPRM1 | |
| SCHEMBL586991 | 0.89 | PLG (0.59) | PLGGABRA1GABRG2GABRB3 | |
| SCHEMBL581408 | 0.88 | PLG (0.45) | PLGGABRA1GABRG2GABRB3 | |
| SCHEMBL582139 | 0.88 | PLG (0.45) | PLGGABRA1GABRG2GABRB3 | |
| SCHEMBL3063068 | 0.88 | PLG (0.45) | PLGGABRA1GABRG2GABRB3 | |
| SCHEMBL581905 | 0.88 | PLG (0.45) | PLGGABRA1GABRG2GABRB3 | |
| SCHEMBL582656 | 0.86 | PLG (0.60) | PLGGABRA1GABRG2GABRB3SIGMAR1 | |
| SCHEMBL27965389 | 0.86 | PLG (0.46) | PLGGABRA1GABRG2GABRB3OPRM1 | |
| SCHEMBL581599 | 0.85 | PLG (0.57) | PLGGABRA1GABRG2GABRB3TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102459246-B | Isoxazol-3 (2H) -one analogs as therapeutic agents | ASTRAZENECA AB | 2014-05-07 | — | — | CN | disclosed |