Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | NR1H4 | Q96RI1 | 2/20 | 0.44 |
| ▸ | RXRA | P19793 | 1/20 | 0.43 |
| ▸ | RXRB | P28702 | 1/20 | 0.43 |
| ▸ | RXRG | P48443 | 1/20 | 0.43 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.40 |
| ▸ | GAA | P10253 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.40 |
| ▸ | XBP1 | P17861 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | NR5A2 | O00482 | 1/20 | 0.39 |
| ▸ | NR5A1 | Q13285 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.39 |
| ▸ | TSHR | P16473 | 2/20 | 0.39 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.39 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.39 |
| ▸ | GLRA3 | O75311 | 1/20 | 0.39 |
| ▸ | GLRB | P48167 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30206727 | 0.94 | NR1H4 (0.48) | NR1H4RXRARXRBRXRGNPSR1 | |
| SCHEMBL265814 | 0.94 | NR1H4 (0.48) | NR1H4RXRARXRBRXRGNPSR1 | |
| Hydrogen Sulfide SCHEMBL28833668 | 0.93 | NR1H4 (0.47) | NR1H4RXRARXRBRXRGNPSR1 | |
| Ethane SCHEMBL19639572 | 0.93 | NR1H4 (0.47) | NR1H4RXRARXRBRXRGNPSR1 | |
| SCHEMBL28295267 | 0.88 | NR1H4 (0.41) | NR1H4RXRARXRBRXRGNPSR1 | |
| SCHEMBL2022443 | 0.87 | NR1H4 (0.43) | NR1H4RXRARXRBRXRGNPSR1 | |
| SCHEMBL27755263 | 0.87 | NR1H4 (0.43) | NR1H4RXRARXRBRXRGNPSR1 | |
| SCHEMBL5607798 | 0.87 | NR1H4 (0.43) | NR1H4RXRARXRBRXRGNPSR1 | |
| SCHEMBL28803599 | 0.87 | NR1H4 (0.43) | NR1H4RXRARXRBRXRGNPSR1 | |
| 1,6-Hexanediol SCHEMBL2954036 | 0.86 | NR1H4 (0.42) | NR1H4RXRARXRBRXRGNPSR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102675819-B | Wear resistant self-lubricating polyformaldehyde and preparation method thereof | YANKUANG LUNAN CHEMICAL FERTILISER PLANT | 2014-05-07 | — | — | CN | disclosed |