Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE10A | Q9Y233 | 10/20 | 0.64 |
| ▸ | LMNA | P02545 | 1/20 | 0.49 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | HTT | P42858 | 1/20 | 0.42 |
| ▸ | KLKB1 | P03952 | 3/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.39 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.39 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.39 |
| ▸ | NR3C2 | P08235 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27975767 | 0.91 | PDE10A (0.61) | PDE10ALMNAALDH1A1HTTCYP3A4 | |
| SCHEMBL2502190 | 0.89 | PDE10A (0.67) | PDE10AALDH1A1HTTCYP1A2CYP3A4 | |
| SCHEMBL27976147 | 0.87 | PDE10A (0.62) | PDE10ALMNAALDH1A1HTTCYP1A2 | |
| SCHEMBL27975801 | 0.87 | PDE10A (0.57) | PDE10ALMNAALDH1A1KLKB1CYP1A2 | |
| SCHEMBL519067 | 0.84 | PDE10A (0.69) | PDE10AALDH1A1HTTCYP2C9 | |
| SCHEMBL518641 | 0.84 | PDE10A (0.70) | PDE10ALMNAALDH1A1HTTCYP1A2 | |
| SCHEMBL27975753 | 0.83 | PDE10A (0.61) | PDE10ALMNAALDH1A1CYP1A2CYP3A4 | |
| SCHEMBL519467 | 0.83 | PDE10A (0.68) | PDE10AALDH1A1HTTCYP1A2CYP3A4 | |
| SCHEMBL518620 | 0.83 | PDE10A (0.71) | PDE10AALDH1A1HTTCYP1A2CYP3A4 | |
| SCHEMBL519303 | 0.83 | PDE10A (0.68) | PDE10AALDH1A1HTTCYP1A2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102365020-B | Pyridazinone compounds | TAKEDA PHARMACEUTICAL | 2014-07-30 | — | — | CN | disclosed |