Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CLK1 | P49759 | 2/20 | 0.74 |
| ▸ | FGFR1 | P11362 | 10/20 | 0.71 |
| ▸ | FGFR2 | P21802 | 4/20 | 0.69 |
| ▸ | FGFR3 | P22607 | 2/20 | 0.69 |
| ▸ | BRAF | P15056 | 1/20 | 0.59 |
| ▸ | DYRK1A | Q13627 | 4/20 | 0.53 |
| ▸ | DYRK3 | O43781 | 2/20 | 0.53 |
| ▸ | CLK2 | P49760 | 2/20 | 0.53 |
| ▸ | GSK3B | P49841 | 2/20 | 0.53 |
| ▸ | CDK5 | Q00535 | 2/20 | 0.53 |
| ▸ | CLK4 | Q9HAZ1 | 2/20 | 0.53 |
| ▸ | PDPK1 | O15530 | 2/20 | 0.53 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.53 |
| ▸ | PLK4 | O00444 | 1/20 | 0.53 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.53 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.53 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.53 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.53 |
| ▸ | ABL1 | P00519 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4791316 | 0.85 | CLK1 (1.00) | CLK1FGFR1FGFR2FGFR3DYRK1A | |
| SCHEMBL2460902 | 0.83 | FGFR1 (1.00) | CLK1FGFR1FGFR2FGFR3DYRK1A | |
| SCHEMBL14663812 | 0.81 | FGFR1 (1.00) | CLK1FGFR1FGFR2FGFR3DYRK1A | |
| SCHEMBL13115655 | 0.81 | FGFR1 (0.71) | CLK1FGFR1FGFR2FGFR3DYRK1A | |
| SCHEMBL27839423 | 0.81 | FGFR1 (0.71) | CLK1FGFR1FGFR2FGFR3DYRK1A | |
| SCHEMBL16935421 | 0.81 | FGFR1 (1.00) | CLK1FGFR1FGFR2FGFR3DYRK1A | |
| SCHEMBL742504 | 0.80 | PIK3CA (0.81) | CLK1FGFR1FGFR2FGFR3BRAF | |
| SCHEMBL28578094 | 0.80 | FGFR1 (0.58) | CLK1FGFR1FGFR2FGFR3DYRK1A | |
| SCHEMBL1318366 | 0.78 | FGFR1 (0.55) | CLK1FGFR1FGFR2FGFR3BRAF | |
| SCHEMBL11295 | 0.77 | FGFR1 (0.65) | CLK1FGFR1FGFR2FGFR3DYRK1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102105462-B | Amidophenoxyindazoles useful as inhibitors of C-MET | LILLY CO ELI | 2014-07-23 | — | — | CN | disclosed |