SCHEMBL27977620

SCHEMBL27977620

N#Cc1cccc(C#N)c1.[H+]

nearest known ligand 0.58

Predicted protein targets (top 9)

geneUniProtsupporting neighboursconfidence
TSHR P16473 1/20 0.58
ENPP2 Q13822 1/20 0.56
CLK4 Q9HAZ1 1/20 0.52
GSK3B P49841 2/20 0.47
DRD2 P14416 1/20 0.47
DRD3 P35462 1/20 0.47
ALDH1A1 P00352 1/20 0.45
MAPT P10636 1/20 0.45
GRM5 P41594 2/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Water SCHEMBL28137572 0.97 TSHR (0.61) TSHRENPP2CLK4GSK3BDRD2
SCHEMBL2817154 0.97 TSHR (0.61) TSHRENPP2CLK4GSK3BDRD2
SCHEMBL9289 0.97 TSHR (0.61) TSHRENPP2CLK4GSK3BDRD2
Hydrochloric Acid SCHEMBL19327577 0.94 TSHR (0.58) TSHRENPP2CLK4GSK3BDRD2
Ammonia Solution, Strong SCHEMBL27601226 0.94 TSHR (0.58) TSHRENPP2CLK4GSK3BDRD2
Fluoride SCHEMBL28362409 0.94 TSHR (0.58) TSHRENPP2CLK4GSK3BDRD2
Cyanide SCHEMBL27586563 0.91 TSHR (0.55) TSHRENPP2CLK4GSK3BDRD2
SCHEMBL28971640 0.91 TSHR (0.63) TSHRENPP2CLK4GSK3BDRD2
SCHEMBL30873480 0.88 GRM5 (0.55) TSHRENPP2GRM5
Hydrazine SCHEMBL28200862 0.88 TSHR (0.52) TSHRENPP2CLK4GSK3BDRD2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104148080-A Catalyst and method for preparing m-xylylenediamine by hydrogen isophthalonitrile CHINA PETROLEUM & CHEMICAL 2014-11-19 CN disclosed
CN-104148080-A Catalyst and method for preparing m-xylylenediamine by hydrogen isophthalonitrile CHINA PETROLEUM & CHEMICAL 2014-11-19 CN disclosed