Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AURKA | O14965 | 9/20 | 0.47 |
| ▸ | PDGFRB | P09619 | 5/20 | 0.47 |
| ▸ | CSF1R | P07333 | 3/20 | 0.47 |
| ▸ | KIT | P10721 | 2/20 | 0.47 |
| ▸ | PDGFRA | P16234 | 2/20 | 0.47 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.46 |
| ▸ | FLT4 | P35916 | 5/20 | 0.42 |
| ▸ | FLT3 | P36888 | 4/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 2/20 | 0.39 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.39 |
| ▸ | KDR | P35968 | 1/20 | 0.39 |
| ▸ | RPS6KA3 | P51812 | 1/20 | 0.39 |
| ▸ | IRAK4 | Q9NWZ3 | 1/20 | 0.39 |
| ▸ | TYK2 | P29597 | 1/20 | 0.38 |
| ▸ | EGFR | P00533 | 2/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL2800072 | 0.99 | AURKA (0.47) | AURKAPDGFRBCSF1RKITPDGFRA | |
| SCHEMBL4640731 | 0.98 | AURKA (0.49) | AURKAPDGFRBCSF1RKITPDGFRA | |
| SCHEMBL4924647 | 0.98 | AURKA (0.49) | AURKAPDGFRBCSF1RKITPDGFRA | |
| Hydrochloric Acid SCHEMBL4924377 | 0.97 | AURKA (0.49) | AURKAPDGFRBCSF1RKITPDGFRA | |
| Hydrochloric Acid SCHEMBL2799704 | 0.94 | AURKA (0.50) | AURKAPDGFRBCSF1RKITPDGFRA | |
| SCHEMBL2800763 | 0.93 | AURKA (0.49) | AURKAPDGFRBCSF1RKITPDGFRA | |
| SCHEMBL3429377 | 0.93 | AURKA (0.52) | AURKAPDGFRBCSF1RKITPDGFRA | |
| SCHEMBL4918469 | 0.91 | AURKA (0.43) | AURKAPDGFRBCSF1RKITPDGFRA | |
| SCHEMBL4923004 | 0.91 | AURKA (0.51) | AURKAPDGFRBCSF1RKITPDGFRA | |
| Hydrochloric Acid SCHEMBL4640373 | 0.90 | AURKA (0.43) | AURKAPDGFRBCSF1RKITPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100168143-A1 | QUINAZOLINE DERIVATIVES | ASTRAZENECA AB | 2010-07-01 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100168143-A1 | QUINAZOLINE DERIVATIVES | CCNI, NQO2, MKI67 | AURKA 342/4885PDGFRB 2351/4885CSF1R 2440/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.