Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IAPP | P10997 | 3/20 | 0.45 |
| ▸ | FFAR4 | Q5NUL3 | 3/20 | 0.42 |
| ▸ | FFAR1 | O14842 | 2/20 | 0.42 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.38 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.38 |
| ▸ | KIF11 | P52732 | 1/20 | 0.38 |
| ▸ | PTPRB | P23467 | 1/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
| ▸ | CYP2C8 | P10632 | 1/20 | 0.36 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.36 |
| ▸ | CYP2B6 | P20813 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | F2RL1 | P55085 | 1/20 | 0.36 |
| ▸ | SLC5A1 | P13866 | 1/20 | 0.36 |
| ▸ | SLC5A2 | P31639 | 1/20 | 0.36 |
| ▸ | POLB | P06746 | 1/20 | 0.36 |
| ▸ | RAB9A | P51151 | 1/20 | 0.36 |
| ▸ | CCR5 | P51681 | 1/20 | 0.35 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL30816271 | 0.87 | FFAR1 (0.55) | FFAR4FFAR1PTPRB | |
| SCHEMBL9247568 | 0.87 | FFAR1 (0.55) | FFAR4FFAR1PTPRB | |
| SCHEMBL3578367 | 0.82 | IAPP (0.49) | IAPPFFAR4FFAR1ALOX5OR51E2 | |
| SCHEMBL31424248 | 0.82 | FFAR1 (0.39) | FFAR4FFAR1PTPRB | |
| SCHEMBL30917811 | 0.81 | CYP1A2 (0.53) | FFAR4FFAR1CYP1A2CYP2C19 | |
| SCHEMBL16840963 | 0.81 | CYP1A2 (0.53) | FFAR4FFAR1CYP1A2CYP2C19 | |
| SCHEMBL14059359 | 0.80 | MAPT (0.50) | FFAR4FFAR1CYP1A2CYP2C19 | |
| SCHEMBL12984627 | 0.79 | CYP4F2 (0.56) | FFAR4FFAR1 | |
| SCHEMBL29021263 | 0.79 | PARP1 (0.36) | FFAR4FFAR1KIF11PTPRBCYP1A2 | |
| SCHEMBL2302020 | 0.79 | KDM4E (0.47) | ALOX5KIF11PTPRBCYP1A2CYP2C9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104024250-B | Heterocyclic derivatives as Trace Amine Associated Receptors (TAARs) | HOFFMAN-LA ROCHE LTD. (CH) | 2016-01-27 | — | — | CN | disclosed |
| CN-104024250-A | HETEROCYCLIC DERIVATIVES AS TRACE AMINE ASSOCIATED RECEPTORS (TAARS) | HOFFMANN LA ROCHE | 2014-09-03 | — | — | CN | disclosed |