Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 16/20 | 0.49 |
| ▸ | DYRK1B | Q9Y463 | 15/20 | 0.49 |
| ▸ | DYRK2 | Q92630 | 14/20 | 0.49 |
| ▸ | CLK1 | P49759 | 14/20 | 0.49 |
| ▸ | CSNK2A2 | P19784 | 2/20 | 0.49 |
| ▸ | CSNK2B | P67870 | 2/20 | 0.49 |
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.49 |
| ▸ | CLK4 | Q9HAZ1 | 12/20 | 0.48 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.48 |
| ▸ | PRKCB | P05771 | 1/20 | 0.48 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.48 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.47 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1418925 | 0.81 | DYRK1A (0.52) | DYRK1ADYRK1BDYRK2CLK1CSNK2A2 | |
| SCHEMBL28015693 | 0.81 | DYRK1A (0.49) | DYRK1ADYRK1BDYRK2CLK1CSNK2A2 | |
| SCHEMBL19140129 | 0.81 | DYRK1A (0.52) | DYRK1ADYRK1BDYRK2CLK1CSNK2A2 | |
| SCHEMBL7218352 | 0.81 | DYRK1A (0.49) | DYRK1ADYRK1BDYRK2CLK1CSNK2A2 | |
| SCHEMBL16693163 | 0.77 | KDM4E (0.47) | DYRK1ADYRK1BDYRK2CLK1CSNK2A2 | |
| SCHEMBL2010188 | 0.74 | NPC1 (0.52) | DYRK1ADYRK1BDYRK2CLK1CSNK2A2 | |
| SCHEMBL23069 | 0.74 | NPC1 (0.56) | DYRK1AKDM4ENPC1RAB9AHKDC1 | |
| SCHEMBL1671036 | 0.74 | NPC1 (0.54) | DYRK1ADYRK1BDYRK2CLK1CLK4 | |
| Cyanide SCHEMBL22130098 | 0.73 | DYRK1A (0.43) | DYRK1ADYRK1BDYRK2CLK1CSNK2A2 | |
| Hydrochloric Acid SCHEMBL27543158 | 0.72 | NPC1 (0.55) | DYRK1AKDM4ENPC1RAB9AHKDC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101918380-B | Substituted benzoazole PDE4 inhibitors for treating inflammatory, cardiovascular and cns disorders | DECODE GENETICS EHF | 2014-09-24 | — | — | CN | claimed |
| CN-101918380-B | Substituted benzoazole PDE4 inhibitors for treating inflammatory, cardiovascular and cns disorders | DECODE GENETICS EHF | 2014-09-24 | — | — | CN | disclosed |