SCHEMBL27982122

Cc1ccccc1-c1ccc(C(N)=O)c2[nH]c3cc(C(=O)N4CCN(C)CC4)ccc3c12

nearest known ligand 1.00 ✓ in ChEMBL — recovers established targets

Predicted protein targets (top 12)

	gene	UniProt	supporting neighbours	confidence
▸	BTK	Q06187	20/20	1.00

▸	JAK2	O60674	2/20	0.83

▸	LCK	P06239	2/20	0.83

▸	LYN	P07948	2/20	0.83

▸	KIT	P10721	2/20	0.83

▸	CDK2	P24941	2/20	0.83

▸	TEC	P42680	2/20	0.83

▸	TXK	P42681	2/20	0.83

▸	BMX	P51813	2/20	0.83

▸	ITK	Q08881	2/20	0.83

▸	AURKA	O14965	1/20	0.83

▸	TYK2	P29597	1/20	0.83

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compound	similarity	top predicted	shared targets
SCHEMBL123341	0.93	BTK (0.86)	BTKJAK2LCKLYNKIT
SCHEMBL123056	0.91	BTK (1.00)	BTKJAK2LCKLYNKIT
SCHEMBL27982107	0.91	BTK (1.00)	BTKJAK2LCKLYNKIT
SCHEMBL27982119	0.90	BTK (0.82)	BTKJAK2LCKLYNKIT
SCHEMBL27982224	0.90	BTK (0.82)	BTKJAK2LCKLYNKIT
SCHEMBL27982130	0.90	BTK (0.85)	BTKJAK2LCKLYNKIT
SCHEMBL27982073	0.89	BTK (1.00)	BTKJAK2LCKLYNKIT
SCHEMBL123555	0.89	BTK (1.00)	BTKJAK2LCKLYNKIT
SCHEMBL27982111	0.89	BTK (1.00)	BTKJAK2LCKLYNKIT
SCHEMBL123558	0.89	BTK (0.80)	BTKJAK2LCKLYNKIT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

Patent	Title	Assignee	Published	Priority	Filing	Country	Status
CN-102325753-B	Carbazole carboxamide compounds useful as kinase inhibitors	BRISTOL MYERS SQUIBB CO	2014-09-10	—	—	CN	claimed