Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.65 |
| ▸ | RAB9A | P51151 | 6/20 | 0.65 |
| ▸ | RUNX1 | Q01196 | 1/20 | 0.62 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 4/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.52 |
| ▸ | NPC1 | O15118 | 5/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.51 |
| ▸ | PKM | P14618 | 2/20 | 0.51 |
| ▸ | METAP2 | P50579 | 2/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | METAP1 | P53582 | 1/20 | 0.51 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.50 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.50 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.50 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.50 |
| ▸ | CDK1 | P06493 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27312758 | 0.84 | KDM4E (0.57) | KDM4ERAB9ARUNX1TDP1HPGD | |
| SCHEMBL31311065 | 0.79 | KDM4E (1.00) | KDM4ERAB9AHPGDALDH1A1KMT2A | |
| SCHEMBL3164011 | 0.79 | KDM4E (1.00) | KDM4ERAB9AHPGDALDH1A1KMT2A | |
| SCHEMBL28388009 | 0.78 | KDM4E (0.97) | KDM4ERAB9AHPGDALDH1A1KMT2A | |
| SCHEMBL27932271 | 0.78 | KDM4E (0.97) | KDM4ERAB9AHPGDALDH1A1KMT2A | |
| SCHEMBL17525960 | 0.77 | RUNX1 (0.84) | KDM4ERAB9ARUNX1TDP1PDE10A | |
| SCHEMBL6530312 | 0.77 | CDK1 (0.69) | KDM4ERAB9AHPGDALDH1A1NPC1 | |
| SCHEMBL15661264 | 0.77 | KDM4E (0.61) | KDM4ERAB9AHPGDALDH1A1KMT2A | |
| SCHEMBL14364615 | 0.76 | CDK1 (0.63) | KDM4ERAB9ATDP1HPGDALDH1A1 | |
| SCHEMBL11471783 | 0.76 | NPC1 (0.61) | KDM4ERAB9AHPGDALDH1A1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-111592508-A | Therapeutic agents based on lanthionine synthase C-like 2 | 朗多生物制药股份有限公司 | 2020-08-28 | — | — | CN | disclosed |
| CN-107108573-B | Therapeutic agents based on lanthionine synthase C-like 2 | 朗多生物制药股份有限公司 | 2020-06-16 | — | — | CN | disclosed |
| US-9567325-B2 | Carboxamide compounds and their use as calpain inhibitors | AbbVie Deutschland GmbH & Co. KG (DE) | 2017-02-14 | — | — | US | disclosed |
| US-20150045394-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | AbbVie Deutschland GmbH & Co. KG (DE) | 2015-02-12 | — | — | US | disclosed |
| US-8906941-B2 | Carboxamide compounds and their use as calpain inhibitors | ABBVIE INC. (US) | 2014-12-09 | — | — | US | disclosed |
| EP-2398783-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | Abbott GmbH & Co. KG (DE) | 2011-12-28 | — | — | EP | disclosed |
| US-20100216844-A1 | Carboxamide compounds and their use as calpain inhibitors | ABBVIE DEUTSCHLAND GMBH & CO KG (DE) | 2010-08-26 | — | — | US | disclosed |
| WO-2010094755-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | ABBOTT GMBH & CO. KG (DE) | 2010-08-26 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20150045394-A1 | CARBOXAMIDE COMPOUNDS AND THEIR USE AS CALPAIN INHIBITORS | CAMK4, CAMK2A, CAMK2B | KDM4E 624/4885RAB9A 3300/4885RUNX1 3773/4885 |
| US-20100216844-A1 | Carboxamide compounds and their use as calpain inhibitors | CAMK4, CAMK2A, CAMK2B | KDM4E 577/4885RAB9A 3299/4885RUNX1 3748/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.