Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDR | P35968 | 7/20 | 0.54 |
| ▸ | DDR2 | Q16832 | 1/20 | 0.50 |
| ▸ | BRAF | P15056 | 11/20 | 0.49 |
| ▸ | RAF1 | P04049 | 6/20 | 0.47 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.47 |
| ▸ | CSF1R | P07333 | 1/20 | 0.45 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.43 |
| ▸ | JAK2 | O60674 | 1/20 | 0.43 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.43 |
| ▸ | ABL1 | P00519 | 1/20 | 0.43 |
| ▸ | LCK | P06239 | 1/20 | 0.43 |
| ▸ | FYN | P06241 | 1/20 | 0.43 |
| ▸ | LYN | P07948 | 1/20 | 0.43 |
| ▸ | RET | P07949 | 1/20 | 0.43 |
| ▸ | ROS1 | P08922 | 1/20 | 0.43 |
| ▸ | SRC | P12931 | 1/20 | 0.43 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.43 |
| ▸ | EPHA2 | P29317 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15574523 | 0.85 | KDR (0.58) | KDRDDR2BRAFRAF1EPHX2 | |
| SCHEMBL2025625 | 0.82 | DDR2 (0.52) | KDRDDR2BRAFRAF1EPHX2 | |
| SCHEMBL15574613 | 0.80 | DDR2 (0.60) | KDRDDR2BRAFRAF1EPHX2 | |
| SCHEMBL6014811 | 0.80 | KDR (0.63) | KDRDDR2BRAFRAF1EPHX2 | |
| SCHEMBL15575218 | 0.79 | DDR2 (0.59) | KDRDDR2BRAFRAF1EPHX2 | |
| SCHEMBL15574246 | 0.79 | DDR2 (0.50) | KDRDDR2BRAFRAF1EPHX2 | |
| SCHEMBL30678636 | 0.78 | DDR2 (0.52) | KDRDDR2BRAFRAF1EPHX2 | |
| SCHEMBL4373389 | 0.78 | KDR (0.52) | KDRDDR2BRAFRAF1EPHX2 | |
| SCHEMBL618015 | 0.77 | KDR (0.59) | KDRBRAFRAF1EPHX2CSF1R | |
| SCHEMBL6014786 | 0.77 | KDR (0.53) | KDRDDR2BRAFRAF1EPHX2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104602690-A | DDR2 inhibitors for the treatment of osteoarthritis | MERCK PATENT GMBH | 2015-05-06 | — | — | CN | disclosed |