Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRD4 | O60885 | 17/20 | 0.79 |
| ▸ | BRD3 | Q15059 | 4/20 | 0.75 |
| ▸ | CREBBP | Q92793 | 4/20 | 0.75 |
| ▸ | BRD7 | Q9NPI1 | 2/20 | 0.75 |
| ▸ | MEN1 | O00255 | 1/20 | 0.69 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.69 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.69 |
| ▸ | USP2 | O75604 | 1/20 | 0.69 |
| ▸ | SLCO2B1 | O94956 | 1/20 | 0.69 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.69 |
| ▸ | CA1 | P00915 | 1/20 | 0.69 |
| ▸ | CA2 | P00918 | 1/20 | 0.69 |
| ▸ | LMNA | P02545 | 1/20 | 0.69 |
| ▸ | MMP1 | P03956 | 1/20 | 0.69 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.69 |
| ▸ | MAPT | P10636 | 1/20 | 0.69 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | TSHR | P16473 | 1/20 | 0.69 |
| ▸ | NFKB1 | P19838 | 1/20 | 0.69 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11430146 | 0.87 | BRD4 (0.76) | BRD4BRD3CREBBPBRD7MEN1 | |
| SCHEMBL29420254 | 0.87 | BRD4 (0.76) | BRD4BRD3CREBBPBRD7MEN1 | |
| SCHEMBL11430139 | 0.87 | BRD4 (0.76) | BRD4BRD3CREBBPBRD7MEN1 | |
| SCHEMBL15496579 | 0.86 | BRD4 (1.00) | BRD4BRD3CREBBPBRD7BAZ2B | |
| SCHEMBL15496569 | 0.86 | BRD4 (1.00) | BRD4BRD3CREBBPBRD7MEN1 | |
| SCHEMBL15496566 | 0.86 | BRD4 (1.00) | BRD4BRD3CREBBPBRD7MEN1 | |
| SCHEMBL30758847 | 0.85 | BRD4 (0.80) | BRD4BRD3CREBBPBRD7MEN1 | |
| SCHEMBL15496570 | 0.84 | BRD4 (1.00) | BRD4BRD3CREBBPBRD7MEN1 | |
| SCHEMBL10242038 | 0.84 | BRD4 (1.00) | BRD4BRD3CREBBPBRD7MEN1 | |
| SCHEMBL15496568 | 0.84 | BRD4 (1.00) | BRD4BRD3CREBBPBRD7MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8134010-B2 | 4-[4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-phenylamine; N-{4-[4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-phenyl}-acetamide; or4-Methyl-5-(2-nitrooxy-ethyl)-2-(4-nitro-phenyl)-thiazole; cardiovascular, gastrointestinal, inflammatory, respiratory disease | RENOPHARM LTD. (IL) | 2012-03-13 | — | — | US | disclosed |
| US-7881871-B2 | Method for designing surfaces | BIO-LAYER PTY LIMITED (AU) | 2011-02-01 | — | — | US | disclosed |
| US-7498445-B2 | Thiazole-based nitric oxide donors capable of releasing two or more nitric oxide molecules and uses thereof | RENOPHARM LTD. (IL) | 2009-03-03 | — | — | US | disclosed |
| US-7368577-B2 | Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof | RENOPHARM LTD. (IL) | 2008-05-06 | — | — | US | disclosed |