Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 14/20 | 0.70 |
| ▸ | MTOR | P42345 | 13/20 | 0.70 |
| ▸ | PIK3R1 | P27986 | 7/20 | 0.67 |
| ▸ | PIK3CG | P48736 | 3/20 | 0.67 |
| ▸ | PIK3CD | O00329 | 2/20 | 0.67 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.67 |
| ▸ | PIK3R5 | Q8WYR1 | 2/20 | 0.67 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.67 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.67 |
| ▸ | PRKDC | P78527 | 1/20 | 0.67 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.67 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.67 |
| ▸ | RICTOR | Q6R327 | 1/20 | 0.57 |
| ▸ | RPTOR | Q8N122 | 1/20 | 0.57 |
| ▸ | MAPKAP1 | Q9BPZ7 | 1/20 | 0.57 |
| ▸ | MLST8 | Q9BVC4 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19460984 | 0.98 | PIK3CA (0.72) | PIK3CAMTORPIK3R1PIK3CGPIK3CD | |
| SCHEMBL19460985 | 0.98 | PIK3CA (0.72) | PIK3CAMTORPIK3R1PIK3CGPIK3CD | |
| SCHEMBL19461013 | 0.98 | PIK3CA (0.72) | PIK3CAMTORPIK3R1PIK3CGPIK3CD | |
| SCHEMBL27995014 | 0.95 | PIK3CA (0.75) | PIK3CAMTORPIK3R1PIK3CGPIK3CD | |
| SCHEMBL15805504 | 0.95 | PIK3CA (0.75) | PIK3CAMTORPIK3R1PIK3CGPIK3CD | |
| SCHEMBL15805511 | 0.93 | PIK3CA (0.78) | PIK3CAMTORPIK3R1PIK3CGPIK3CD | |
| SCHEMBL15805513 | 0.93 | PIK3CA (0.78) | PIK3CAMTORPIK3R1PIK3CGPIK3CD | |
| SCHEMBL15805510 | 0.93 | PIK3CA (0.78) | PIK3CAMTORPIK3R1PIK3CGPIK3CD | |
| SCHEMBL15805520 | 0.93 | PIK3CA (0.78) | PIK3CAMTORPIK3R1PIK3CGPIK3CD | |
| SCHEMBL15805509 | 0.93 | PIK3CA (0.78) | PIK3CAMTORPIK3R1PIK3CGPIK3CD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104245693-A | Pyrimidine derivative and pharmaceutically acceptable salt thereof, preparation method and medical application thereof | SHANGHAI HENGRUI PHARM CO LTD | 2014-12-24 | — | — | CN | disclosed |