Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.44 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.44 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.44 |
| ▸ | NAAA | Q02083 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.36 |
| ▸ | RAD52 | P43351 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.35 |
| ▸ | TSHR | P16473 | 2/20 | 0.35 |
| ▸ | LMNA | P02545 | 2/20 | 0.35 |
| ▸ | FAAH | O00519 | 1/20 | 0.35 |
| ▸ | HTR2C | P28335 | 1/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.34 |
| ▸ | HSD17B10 | Q99714 | 2/20 | 0.34 |
| ▸ | POLB | P06746 | 1/20 | 0.34 |
| ▸ | DGKA | P23743 | 1/20 | 0.34 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | HPGD | P15428 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL6115511 | 0.93 | MEN1 (0.50) | MEN1HSP90AA1KMT2ASMN1; SMN2NAAA | |
| Bromide SCHEMBL2292021 | 0.93 | MEN1 (0.50) | MEN1HSP90AA1KMT2ASMN1; SMN2NAAA | |
| Bromide SCHEMBL1412163 | 0.93 | MEN1 (0.50) | MEN1HSP90AA1KMT2ASMN1; SMN2NAAA | |
| SCHEMBL15402942 | 0.91 | MEN1 (0.36) | MEN1HSP90AA1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL12419203 | 0.91 | MEN1 (0.48) | MEN1HSP90AA1KMT2ASMN1; SMN2NAAA | |
| Bromide SCHEMBL2293055 | 0.91 | MEN1 (0.48) | MEN1HSP90AA1KMT2ASMN1; SMN2NAAA | |
| SCHEMBL805595 | 0.90 | MEN1 (0.46) | MEN1HSP90AA1KMT2ASMN1; SMN2NAAA | |
| Bromide SCHEMBL2296154 | 0.87 | MEN1 (0.46) | MEN1HSP90AA1KMT2ASMN1; SMN2NAAA | |
| Bromide SCHEMBL6115324 | 0.87 | MEN1 (0.41) | MEN1HSP90AA1KMT2ASMN1; SMN2ALDH1A1 | |
| SCHEMBL2288348 | 0.86 | MEN1 (0.43) | MEN1HSP90AA1KMT2ASMN1; SMN2NAAA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2010135660-A2 | IONIC LIQUID MEDIATED SOL-GEL SORBENTS | UNIVERSITY OF SOUTH FLORIDA (US) | 2010-11-25 | — | — | WO | disclosed |