Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PPARD | Q03181 | 8/20 | 0.41 |
| ▸ | PPARA | Q07869 | 6/20 | 0.41 |
| ▸ | PPARG | P37231 | 5/20 | 0.41 |
| ▸ | PTPN1 | P18031 | 5/20 | 0.40 |
| ▸ | FFAR1 | O14842 | 4/20 | 0.39 |
| ▸ | MAPT | P10636 | 3/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL280042 | 0.85 | MAPT (0.38) | PPARDPPARAPPARGPTPN1FFAR1 | |
| SCHEMBL279236 | 0.84 | PPARD (0.55) | PPARDPPARAPPARGFFAR1MAPT | |
| SCHEMBL279538 | 0.82 | MAPT (0.38) | PPARDPPARAPPARGPTPN1MAPT | |
| SCHEMBL264030 | 0.81 | PPARD (0.41) | PPARDPPARAPPARGPTPN1FFAR1 | |
| SCHEMBL3527473 | 0.81 | PPARD (0.42) | PPARDPPARAPPARGFFAR1MAPT | |
| SCHEMBL14210415 | 0.80 | PPARD (0.39) | PPARDPPARAPPARGPTPN1FFAR1 | |
| SCHEMBL280312 | 0.80 | MAPT (0.47) | PPARDFFAR1MAPTLMNATP53 | |
| SCHEMBL10207172 | 0.79 | PPARD (0.52) | PPARDPPARAPPARGPTPN1FFAR1 | |
| SCHEMBL279349 | 0.79 | MAPT (0.36) | PPARDPPARAPPARGPTPN1FFAR1 | |
| SCHEMBL279959 | 0.78 | MAPT (0.53) | PPARDPPARAPPARGPTPN1FFAR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8134010-B2 | 4-[4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-phenylamine; N-{4-[4-Methyl-5-(2-nitrooxy-ethyl)-thiazol-2-yl]-phenyl}-acetamide; or4-Methyl-5-(2-nitrooxy-ethyl)-2-(4-nitro-phenyl)-thiazole; cardiovascular, gastrointestinal, inflammatory, respiratory disease | RENOPHARM LTD. (IL) | 2012-03-13 | — | — | US | disclosed |
| US-7968575-B2 | Nitric oxide donors and uses thereof | RENOPHARM LTD. (IL) | 2011-06-28 | — | — | US | disclosed |
| US-7579477-B2 | Thiazole-based nitric oxide donors having alkyl substituent(s) and uses thereof | RENOPHARM LTD. (IL) | 2009-08-25 | — | — | US | disclosed |
| US-7498445-B2 | Thiazole-based nitric oxide donors capable of releasing two or more nitric oxide molecules and uses thereof | RENOPHARM LTD. (IL) | 2009-03-03 | — | — | US | disclosed |
| US-7368577-B2 | Thiazole-based nitric oxide donors having aryl substituent(s) and uses thereof | RENOPHARM LTD. (IL) | 2008-05-06 | — | — | US | disclosed |
| US-7332513-B2 | Thiazole-based nitric oxide donors having acyl substituent(s) and uses thereof | RENOPHARM LTD. (IL) | 2008-02-19 | — | — | US | disclosed |