SCHEMBL28010075

SCHEMBL28010075

COc1cc2ncnc(Sc3cccc(NC(=O)Nc4ccc(CN)cc4)c3)c2cc1OC

nearest known ligand 0.77

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
BRAF P15056 20/20 0.77
RAF1 P04049 8/20 0.77

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17053428 0.89 BRAF (0.80) BRAFRAF1
SCHEMBL28010078 0.89 BRAF (0.81) BRAFRAF1
SCHEMBL1015407 0.87 BRAF (1.00) BRAFRAF1
SCHEMBL1015631 0.86 BRAF (1.00) BRAFRAF1
SCHEMBL28009531 0.86 BRAF (0.82) BRAFRAF1
SCHEMBL1782126 0.85 BRAF (0.72) BRAFRAF1
SCHEMBL1013794 0.84 BRAF (1.00) BRAFRAF1
SCHEMBL1016227 0.84 BRAF (1.00) BRAFRAF1
SCHEMBL1012798 0.83 BRAF (1.00) BRAFRAF1
SCHEMBL1015220 0.82 BRAF (1.00) BRAFRAF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104892530-A Diaryl urea compound containing quinazoline structure as well as preparation method and application thereof UNIV YANTAI 2015-09-09 CN disclosed