Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 17/20 | 0.70 |
| ▸ | PDE2A | O00408 | 1/20 | 0.69 |
| ▸ | PDE9A | O76083 | 1/20 | 0.69 |
| ▸ | PDE4A | P27815 | 1/20 | 0.69 |
| ▸ | PDE6C | P51160 | 1/20 | 0.69 |
| ▸ | PDE1A | P54750 | 1/20 | 0.69 |
| ▸ | PDE11A | Q9HCR9 | 1/20 | 0.69 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.69 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.64 |
| ▸ | POLB | P06746 | 1/20 | 0.60 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.59 |
| ▸ | PDE3B | Q13370 | 1/20 | 0.57 |
| ▸ | PDE3A | Q14432 | 1/20 | 0.57 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2799590 | 0.95 | PDE5A (0.66) | PDE5APDE2APDE9APDE4APDE6C | |
| SCHEMBL2799100 | 0.94 | PDE5A (0.67) | PDE5APDE2APDE9APDE4APDE6C | |
| SCHEMBL2800685 | 0.93 | PDE5A (0.63) | PDE5APDE2APDE9APDE4APDE6C | |
| SCHEMBL2800423 | 0.91 | KDM4E (0.77) | PDE5APDE2APDE9APDE4APDE6C | |
| SCHEMBL2798880 | 0.90 | PDE5A (0.65) | PDE5APDE2APDE9APDE4APDE6C | |
| SCHEMBL2802513 | 0.90 | PDE5A (0.62) | PDE5APDE2APDE9APDE4APDE6C | |
| SCHEMBL2801358 | 0.89 | PDE5A (0.72) | PDE5APDE2APDE9APDE4APDE6C | |
| SCHEMBL2803636 | 0.89 | KDM4E (0.69) | PDE5APDE2APDE9APDE4APDE6C | |
| SCHEMBL2802379 | 0.89 | PDE5A (0.66) | PDE5APDE2APDE9APDE4APDE6C | |
| SCHEMBL2801945 | 0.89 | KDM4E (0.66) | PDE5APDE2APDE9APDE4APDE6C |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2253632-A1 | Pyrazolopyramidinone derivatives, their preparation and their use | Topharman Shanghai Co., Ltd. (CN) | 2010-11-24 | — | — | EP | disclosed |
| EP-1961753-A1 | PYRAZOLOPYRIMIDINONE DERIVATIVES, THEIR PREPARATION AND THEIR USE | Topharman Shanghai Co., Ltd. (CN) | 2008-08-27 | — | — | EP | disclosed |