SCHEMBL28014689

SCHEMBL28014689

O=C(O)c1ccc(C(O)(C(=O)O)c2ccccc2)cc1

nearest known ligand 0.64

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2C9 P11712 2/20 0.64
TSHR P16473 2/20 0.52
DAO P14920 1/20 0.52
NAPRT Q6XQN6 1/20 0.52
SRD5A2 P31213 5/20 0.50
CYP2D6 P10635 1/20 0.50
HIF1A Q16665 1/20 0.50
CES2 O00748 1/20 0.50
CES1 P23141 1/20 0.50
TP53 P04637 1/20 0.50
CYP1A2 P05177 2/20 0.46
MEN1 O00255 1/20 0.46
KMT2A Q03164 1/20 0.46
TRPA1 O75762 1/20 0.45
KIF11 P52732 1/20 0.45
RXRA P19793 1/20 0.43
RXRB P28702 1/20 0.43
RARB P10826 1/20 0.43
RARG P13631 1/20 0.43
CA12 O43570 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15367600 0.94 CYP2C9 (0.59) CYP2C9TSHRDAONAPRTSRD5A2
Benzylic Acid SCHEMBL7066 0.87 CYP2C9 (0.74) CYP2C9TSHRCYP2D6HIF1ACYP1A2
Benzylic Acid SCHEMBL5705762 0.84 CYP2C9 (0.71) CYP2C9TSHRCYP2D6HIF1ACYP1A2
Benzylic Acid SCHEMBL9181980 0.84 CYP2C9 (0.71) CYP2C9TSHRCYP2D6HIF1ACYP1A2
Benzylic Acid SCHEMBL2810363 0.84 CYP2C9 (0.71) CYP2C9TSHRCYP2D6HIF1ACYP1A2
Benzylic Acid SCHEMBL1680669 0.84 CYP2C9 (0.71) CYP2C9TSHRCYP2D6HIF1ACYP1A2
Benzylic Acid SCHEMBL11049826 0.84 CYP2C9 (0.71) CYP2C9TSHRCYP2D6HIF1ACYP1A2
Benzylic Acid SCHEMBL9568239 0.84 CYP2C9 (0.71) CYP2C9TSHRCYP2D6HIF1ACYP1A2
Benzylic Acid SCHEMBL20957595 0.84 CYP2C9 (0.71) CYP2C9TSHRCYP2D6HIF1ACYP1A2
Benzylic Acid SCHEMBL1681667 0.84 CYP2C9 (0.71) CYP2C9TSHRCYP2D6HIF1ACYP1A2

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-103221341-B Surface-modified silica powder and method for producing the same, as well as toner composition for electrophotography NIPPON AEROSIL CO LTD 2015-06-10 CN disclosed