Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Acrylic Acid Methyl Ester. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HCAR2 | Q8TDS4 | 2/20 | 0.42 |
| ▸ | KEAP1 | Q14145 | 1/20 | 0.42 |
| ▸ | NFE2L2 | Q16236 | 1/20 | 0.42 |
| ▸ | CA5A | P35218 | 1/20 | 0.38 |
| ▸ | CA5B | Q9Y2D0 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 7/20 | 0.35 |
| ▸ | HPGD | P15428 | 2/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 6/20 | 0.33 |
| ▸ | TP53 | P04637 | 3/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 3/20 | 0.33 |
| ▸ | CYP3A4 | P08684 | 2/20 | 0.33 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.33 |
| ▸ | TGM2 | P21980 | 1/20 | 0.32 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.32 |
| ▸ | MAPT | P10636 | 2/20 | 0.32 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.32 |
| ▸ | MEN1 | O00255 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.32 |
| ▸ | CACNA1B | Q00975 | 1/20 | 0.32 |
| ▸ | APBA1 | Q02410 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Acrylic Acid Methyl Ester SCHEMBL8029669 | 0.94 | HCAR2 (0.37) | HCAR2KEAP1NFE2L2CA5ACA5B | |
| Acrylic Acid Methyl Ester SCHEMBL27464549 | 0.92 | HCAR2 (0.36) | HCAR2KEAP1NFE2L2CA5ACA5B | |
| Acrylic Acid Methyl Ester SCHEMBL9108 | 0.84 | — | — | |
| Acrylic Acid Methyl Ester SCHEMBL1854813 | 0.84 | HCAR2 (0.56) | HCAR2KEAP1NFE2L2TSHRHPGD | |
| Acrylic Acid Methyl Ester SCHEMBL7645157 | 0.84 | HCAR2 (0.56) | HCAR2KEAP1NFE2L2TSHRHPGD | |
| Acrylic Acid Methyl Ester SCHEMBL756906 | 0.82 | — | — | |
| Acrylic Acid Methyl Ester SCHEMBL375692 | 0.82 | — | — | |
| Acrylic Acid Methyl Ester SCHEMBL10616621 | 0.82 | — | — | |
| Acrylic Acid Methyl Ester SCHEMBL2957775 | 0.82 | — | — | |
| Acrylic Acid Methyl Ester SCHEMBL21272174 | 0.82 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104797363-B | Method for making silver nanostructures and copolymers useful in such method | 罗地亚经营管理公司 | 2018-09-07 | — | — | CN | claimed |
| CN-104797363-B | Method for making silver nanostructures and copolymers useful in such method | 罗地亚经营管理公司 | 2018-09-07 | — | — | CN | disclosed |
| CN-104797363-A | Method for making silver nanostructures and copolymers useful in such method | RHODIA OPERATIONS | 2015-07-22 | — | — | CN | disclosed |