Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | STIM1 | Q13586 | 2/20 | 0.38 |
| ▸ | ORAI1 | Q96D31 | 2/20 | 0.38 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.35 |
| ▸ | HDAC4 | P56524 | 1/20 | 0.35 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.35 |
| ▸ | HDAC7 | Q8WUI4 | 1/20 | 0.35 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.35 |
| ▸ | HDAC10 | Q969S8 | 1/20 | 0.35 |
| ▸ | HDAC11 | Q96DB2 | 1/20 | 0.35 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.35 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.35 |
| ▸ | HDAC9 | Q9UKV0 | 1/20 | 0.35 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 4/20 | 0.35 |
| ▸ | NPC1 | O15118 | 3/20 | 0.35 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.35 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.35 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.32 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28019091 | 0.87 | HDAC3 (0.38) | STIM1ORAI1HDAC3HDAC4HDAC1 | |
| SCHEMBL2470821 | 0.82 | EGLN1 (0.45) | STIM1ORAI1HDAC3HDAC4HDAC1 | |
| SCHEMBL2514434 | 0.79 | PRMT5 (0.42) | STIM1ORAI1HDAC3HDAC4HDAC1 | |
| SCHEMBL2472709 | 0.77 | STIM1 (0.37) | STIM1ORAI1HDAC3HDAC4HDAC1 | |
| SCHEMBL2473839 | 0.77 | EGLN1 (0.43) | STIM1ORAI1HDAC3HDAC4HDAC1 | |
| SCHEMBL28019595 | 0.75 | HDAC4 (0.35) | HDAC4HDAC2HDAC8HDAC6KDM4E | |
| SCHEMBL4186323 | 0.75 | CARM1 (0.35) | STIM1ORAI1HDAC3HDAC4HDAC1 | |
| SCHEMBL2471307 | 0.68 | EGLN1 (0.42) | STIM1ORAI1HDAC3HDAC4HDAC1 | |
| SCHEMBL2761892 | 0.68 | EGLN1 (0.47) | STIM1ORAI1EGLN2 | |
| SCHEMBL4345184 | 0.68 | STIM1 (0.35) | STIM1ORAI1HDAC3HDAC4HDAC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105037323-A | Thiochromene derivatives as HIF hydroxylase inhibitors | FIBROGEN INC | 2015-11-11 | — | — | CN | claimed |
| CN-105037323-A | Thiochromene derivatives as HIF hydroxylase inhibitors | FIBROGEN INC | 2015-11-11 | — | — | CN | disclosed |
| CN-102272117-B | Benzothiopyran derivatives as HIF hydroxylase inhibitors | FIBROGEN INC | 2015-06-17 | — | — | CN | disclosed |