Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | DYRK1A | Q13627 | 3/20 | 0.46 |
| ▸ | GSK3B | P49841 | 2/20 | 0.46 |
| ▸ | LRRK2 | Q5S007 | 2/20 | 0.46 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.46 |
| ▸ | PIM1 | P11309 | 2/20 | 0.46 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.46 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.46 |
| ▸ | JAK2 | O60674 | 1/20 | 0.46 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.46 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.46 |
| ▸ | PAK4 | O96013 | 1/20 | 0.46 |
| ▸ | ABL1 | P00519 | 1/20 | 0.46 |
| ▸ | LCK | P06239 | 1/20 | 0.46 |
| ▸ | FYN | P06241 | 1/20 | 0.46 |
| ▸ | CSF1R | P07333 | 1/20 | 0.46 |
| ▸ | RET | P07949 | 1/20 | 0.46 |
| ▸ | IGF1R | P08069 | 1/20 | 0.46 |
| ▸ | MET | P08581 | 1/20 | 0.46 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26259989 | 0.78 | CYP2A6 (0.64) | DYRK1AGSK3BLRRK2NUDT1CYP11B1 | |
| SCHEMBL21160911 | 0.75 | CYP11B1 (0.51) | FYNACVR1NUDT1CYP11B1CYP11B2 | |
| SCHEMBL1924022 | 0.73 | CYP2A6 (0.50) | DYRK1AGSK3BAURKAAURKBNUDT1 | |
| SCHEMBL12339131 | 0.73 | CYP2A6 (0.54) | DYRK1ADYRK1BNUDT1CYP11B1CYP11B2 | |
| SCHEMBL13727366 | 0.72 | CYP11B1 (0.58) | LRRK2LCKCLK4CYP11B1CYP11B2 | |
| SCHEMBL28139442 | 0.72 | CYP2A6 (0.48) | DYRK1AGSK3BCLK4NUDT1CYP11B1 | |
| SCHEMBL4789914 | 0.71 | CYP2A6 (0.48) | DYRK1AGSK3BNUDT1CYP11B1CYP3A4 | |
| SCHEMBL13727852 | 0.71 | CYP11B1 (0.57) | LRRK2LCKCLK4CYP11B1CYP11B2 | |
| SCHEMBL13907276 | 0.70 | CYP11B1 (0.66) | DYRK1AGSK3BLRRK2NUDT1CYP11B1 | |
| SCHEMBL10296012 | 0.70 | CYP11B1 (0.66) | LRRK2NUDT1CYP11B1CYP11B2CYP3A4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104837832-B | GDF-8 inhibitors | 里格尔药品股份有限公司 | 2019-04-26 | — | — | CN | claimed |
| CN-104837832-A | GDF-8 inhibitors | RIGEL PHARMACEUTICALS INC | 2015-08-12 | — | — | CN | claimed |
| CN-104837832-B | GDF-8 inhibitors | 里格尔药品股份有限公司 | 2019-04-26 | — | — | CN | disclosed |
| CN-106536507-A | 2,3-disubstituted pyridine compounds as TGF-beta inhibitors and methods of use | 里格尔药品股份有限公司 | 2017-03-22 | — | — | CN | disclosed |
| CN-104837832-A | GDF-8 inhibitors | RIGEL PHARMACEUTICALS INC | 2015-08-12 | — | — | CN | disclosed |