Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.39 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
| ▸ | HRH4 | Q9H3N8 | 16/20 | 0.36 |
| ▸ | NPC1 | O15118 | 2/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
| ▸ | NOD2 | Q9HC29 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9884175 | 1.00 | MEN1 (0.39) | MEN1KMT2AHRH4NPC1LMNA | |
| SCHEMBL9883831 | 1.00 | MEN1 (0.39) | MEN1KMT2AHRH4NPC1LMNA | |
| SCHEMBL9884153 | 0.87 | HRH4 (0.34) | HRH4LMNAMAPTSMN1; SMN2 | |
| SCHEMBL9883833 | 0.87 | HRH4 (0.35) | HRH4 | |
| SCHEMBL9883829 | 0.87 | HRH4 (0.34) | HRH4LMNAMAPTSMN1; SMN2 | |
| SCHEMBL9884141 | 0.87 | HRH4 (0.35) | HRH4 | |
| SCHEMBL604574 | 0.87 | HRH4 (0.35) | HRH4 | |
| SCHEMBL601527 | 0.87 | HRH4 (0.34) | HRH4LMNAMAPTSMN1; SMN2 | |
| SCHEMBL604899 | 0.86 | HRH4 (0.36) | HRH4 | |
| SCHEMBL9884121 | 0.86 | HRH4 (0.36) | HRH4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 24 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2200595-B1 | THIENO-AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2013-11-20 | — | — | EP | claimed |
| US-8445482-B2 | Thieno- and furo-pyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2013-05-21 | — | — | US | claimed |
| US-20120270855-A1 | THIENO- AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | EDWARDS JAMES P (US) | 2012-10-25 | — | — | US | claimed |
| US-20120238544-A1 | THIENO- AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | Timoneda, Jesús Joanós i | 2012-09-20 | — | — | US | claimed |
| US-20120214792-A1 | THIENO- ADN FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | EDWARDS JAMES P (US) | 2012-08-23 | — | — | US | claimed |
| US-20120208793-A1 | THIENO- AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | Timoneda, Jesús Joanós | 2012-08-16 | — | — | US | claimed |
| EP-2200595-A2 | THIENO-AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | Janssen Pharmaceutica, N.V. (BE) | 2010-06-30 | — | — | EP | claimed |
| WO-2009038673-A2 | THIENO-AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-26 | — | — | WO | claimed |
| US-20090075970-A1 | Thieno-and furo-pyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-19 | — | — | US | claimed |
| US-8937075-B2 | Thieno- and furo-pyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA, NV (BE) | 2015-01-20 | — | — | US | disclosed |
| US-8937075-B2 | Thieno- and furo-pyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA, NV (BE) | 2015-01-20 | — | — | US | disclosed |
| US-8927555-B2 | Thieno- and furo-pyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA, NV (BE) | 2015-01-06 | — | — | US | disclosed |
| US-8927555-B2 | Thieno- and furo-pyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA, NV (BE) | 2015-01-06 | — | — | US | disclosed |
| EP-2200595-B1 | THIENO-AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | JANSSEN PHARMACEUTICA NV (BE) | 2013-11-20 | — | — | EP | disclosed |
| US-20120270855-A1 | THIENO- AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | EDWARDS JAMES P (US) | 2012-10-25 | — | — | US | disclosed |
| US-20120238544-A1 | THIENO- AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | Timoneda, Jesús Joanós i | 2012-09-20 | — | — | US | disclosed |
| US-20120214792-A1 | THIENO- ADN FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | EDWARDS JAMES P (US) | 2012-08-23 | — | — | US | disclosed |
| US-20120208793-A1 | THIENO- AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | Timoneda, Jesús Joanós | 2012-08-16 | — | — | US | disclosed |
| US-8193178-B2 | Thieno- and furo-pyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA NV (BE) | 2012-06-05 | — | — | US | disclosed |
| US-20090075970-A1 | Thieno-and furo-pyrimidine modulators of the histamine H4 receptor | JANSSEN PHARMACEUTICA N.V. (BE) | 2009-03-19 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20120208793-A1 | THIENO- AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | HRH4, HRH3, HRH2 | MEN1 4118/4885KMT2A 1156/4885HRH4 1/4885 |
| US-20090075970-A1 | Thieno-and furo-pyrimidine modulators of the histamine H4 receptor | HRH4, HRH3, HRH2 | MEN1 4118/4885KMT2A 1156/4885HRH4 1/4885 |
| US-20120238544-A1 | THIENO- AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | HRH4, HRH3, HRH2 | MEN1 4118/4885KMT2A 1156/4885HRH4 1/4885 |
| US-20120214792-A1 | THIENO- ADN FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | HRH4, HRH3, HRH2 | MEN1 3864/4885KMT2A 1542/4885HRH4 1/4885 |
| US-20120270855-A1 | THIENO- AND FURO-PYRIMIDINE MODULATORS OF THE HISTAMINE H4 RECEPTOR | HRH4, HRH3, HRH2 | MEN1 4118/4885KMT2A 1156/4885HRH4 1/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.