Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | BRAF | P15056 | 19/20 | 0.72 |
| ▸ | RAF1 | P04049 | 18/20 | 0.72 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.62 |
| ▸ | HSPB1 | P04792 | 1/20 | 0.62 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.62 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.62 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28025220 | 0.88 | BRAF (0.72) | BRAFRAF1MAPK13HSPB1MAPK12 | |
| SCHEMBL16034999 | 0.83 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL16034935 | 0.83 | BRAF (1.00) | BRAFRAF1MAPK13HSPB1MAPK12 | |
| SCHEMBL16036704 | 0.83 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL17523467 | 0.83 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL16034819 | 0.82 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL16121759 | 0.82 | BRAF (1.00) | BRAFRAF1 | |
| SCHEMBL28024736 | 0.82 | RAF1 (0.56) | BRAFRAF1 | |
| SCHEMBL17526025 | 0.81 | BRAF (0.77) | BRAFRAF1 | |
| SCHEMBL16035246 | 0.80 | BRAF (1.00) | BRAFRAF1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143209-A | Biaryl amide compounds as kinase inhibitors | NOVARTIS AG | 2015-12-09 | — | — | CN | disclosed |