SCHEMBL28024731

SCHEMBL28024731

C[C@@H](C#N)Oc1ncc(-c2cc(NC(=O)c3cccc(C(F)(F)F)c3)ccc2CN)cc1N1CCOCC1

nearest known ligand 0.82

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
RAF1 P04049 20/20 0.82
BRAF P15056 20/20 0.82

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28025193 1.00 RAF1 (0.82) RAF1BRAF
SCHEMBL28025279 0.93 RAF1 (0.81) RAF1BRAF
SCHEMBL16034795 0.90 RAF1 (1.00) RAF1BRAF
SCHEMBL16034896 0.90 RAF1 (1.00) RAF1BRAF
SCHEMBL16034796 0.90 RAF1 (1.00) RAF1BRAF
SCHEMBL28821465 0.85 RAF1 (0.81) RAF1BRAF
SCHEMBL16036529 0.83 RAF1 (1.00) RAF1BRAF
SCHEMBL16094468 0.82 RAF1 (0.88) RAF1BRAF
SCHEMBL28024727 0.81 RAF1 (0.81) RAF1BRAF
SCHEMBL16034658 0.81 RAF1 (1.00) RAF1BRAF

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105143209-A Biaryl amide compounds as kinase inhibitors NOVARTIS AG 2015-12-09 CN disclosed