SCHEMBL28024929

SCHEMBL28024929

N#Cc1cccc(Cl)c1C(F)(F)F

nearest known ligand 0.45

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
AR P10275 15/20 0.45
NOTUM Q6P988 1/20 0.42
DYRK1A Q13627 1/20 0.41
KDM4E B2RXH2 1/20 0.36
MEN1 O00255 1/20 0.36
ALDH1A1 P00352 1/20 0.36
GAA P10253 1/20 0.36
MAPT P10636 1/20 0.36
HPGD P15428 1/20 0.36
ALOX15 P16050 1/20 0.36
CASP1 P29466 1/20 0.36
KMT2A Q03164 1/20 0.36
HSD17B10 Q99714 1/20 0.36
PDK2 Q15119 1/20 0.36
LDHA P00338 1/20 0.36
LDHB P07195 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL25983090 0.85 AR (0.46) ARPDK2
SCHEMBL21718388 0.82 DYRK1A (0.42) ARDYRK1AKDM4EMEN1ALDH1A1
SCHEMBL8722602 0.78 NOTUM (0.50) NOTUMMEN1ALDH1A1KMT2APDK2
SCHEMBL1994873 0.78 AR (0.41) ARPDK2
SCHEMBL3911267 0.78 AR (0.46) AR
SCHEMBL29378798 0.78 AR (0.41) ARPDK2
SCHEMBL14699104 0.76 DYRK1A (0.42) ARNOTUMDYRK1APDK2
SCHEMBL2134651 0.76 DYRK1A (0.41) ARDYRK1APDK2
SCHEMBL2658869 0.76 AR (0.40) ARPDK2
SCHEMBL5228912 0.76 TSHR (0.54) AR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-111153758-B Method for catalyzing aromatic halogen-containing organic matter dehalogenation by using supported metal oxide 浙江大学 2021-06-08 CN claimed
CN-111153758-A Method for catalyzing aromatic halogen-containing organic matter dehalogenation by using supported metal oxide 浙江大学 2020-05-15 CN claimed
CN-111153758-B Method for catalyzing aromatic halogen-containing organic matter dehalogenation by using supported metal oxide 浙江大学 2021-06-08 CN disclosed
CN-111153758-A Method for catalyzing aromatic halogen-containing organic matter dehalogenation by using supported metal oxide 浙江大学 2020-05-15 CN disclosed
CN-104803916-B Hete rocyclic derivatives as SARM (SARMS) 詹森药业有限公司 2017-08-11 CN disclosed
CN-104803916-A Novel heterocycle derivatives useful as selective androgen receptor modulators (sarms) JANSSEN PHARMACEUTICA NV 2015-07-29 CN disclosed