SCHEMBL28025178

SCHEMBL28025178

O=[SH](=O)Cc1nc(Cl)cc(N2CCOCC2)n1

nearest known ligand 0.56

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
CYP1A2 P05177 1/20 0.56
CYP2D6 P10635 1/20 0.56
MAPT P10636 1/20 0.56
KMT2A Q03164 4/20 0.52
RAF1 P04049 1/20 0.46
BRAF P15056 1/20 0.46
MEN1 O00255 2/20 0.40
POLB P06746 2/20 0.40
PRKDC P78527 1/20 0.40
PIK3CB P42338 5/20 0.39
PIK3CD O00329 2/20 0.39
NPC1 O15118 1/20 0.39
RAB9A P51151 1/20 0.39
HTT P42858 1/20 0.39
CRHBP P24387 1/20 0.39
CRHR2 Q13324 1/20 0.39
PIK3CA P42336 1/20 0.39
KDM4E B2RXH2 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL18398994 0.81 CYP1A2 (0.60) CYP1A2CYP2D6MAPTKMT2ARAF1
SCHEMBL3598467 0.81 MAPT (0.60) CYP1A2CYP2D6MAPTKMT2ARAF1
SCHEMBL13141217 0.81 MAPT (0.60) CYP1A2CYP2D6MAPTKMT2ARAF1
SCHEMBL3599828 0.81 CYP1A2 (0.60) CYP1A2CYP2D6MAPTKMT2ARAF1
SCHEMBL3601715 0.81 MAPT (0.65) CYP1A2CYP2D6MAPTKMT2ARAF1
SCHEMBL3600627 0.78 MAPT (0.61) CYP1A2CYP2D6MAPTKMT2ARAF1
SCHEMBL27790168 0.78 MAPT (0.57) CYP1A2CYP2D6MAPTKMT2ARAF1
SCHEMBL3610060 0.78 CYP1A2 (0.57) CYP1A2CYP2D6MAPTKMT2ARAF1
SCHEMBL3600781 0.77 CYP1A2 (0.56) CYP1A2CYP2D6MAPTKMT2ARAF1
SCHEMBL13119748 0.77 CYP1A2 (0.56) CYP1A2CYP2D6MAPTKMT2ARAF1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108467369-A BIARYL AMIDE COMPOUNDS AS KINASE INHIBITORS 诺华股份有限公司 2018-08-31 CN disclosed
CN-105143209-B Biaryl amide compounds as kinase inhibitors 诺华股份有限公司 2018-03-13 CN disclosed
CN-105143209-A Biaryl amide compounds as kinase inhibitors NOVARTIS AG 2015-12-09 CN disclosed