Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 19/20 | 0.58 |
| ▸ | PDE4A | P27815 | 12/20 | 0.58 |
| ▸ | PDE4C | Q08493 | 12/20 | 0.58 |
| ▸ | PDE4D | Q08499 | 12/20 | 0.58 |
| ▸ | HTR2B | P41595 | 1/20 | 0.50 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL29966493 | 0.91 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL28874609 | 0.91 | PDE4B (0.55) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL15194522 | 0.85 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL22149144 | 0.85 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL18315415 | 0.85 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL29689563 | 0.85 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL23365792 | 0.85 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL18679863 | 0.85 | PDE4B (0.61) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL22790744 | 0.83 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DHTR2B | |
| SCHEMBL15580926 | 0.82 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DHTR2B |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105461602-B | The preparation method of the chiral methoxyl group α of 3 ethyoxyl of S or R 4 [(mesyl) methyl] phenmethylol | 东华大学 | 2018-01-02 | — | — | CN | claimed |
| CN-105330586-B | A kind of preparation method of Apremilast | 东华大学 | 2017-12-22 | — | — | CN | claimed |
| CN-105461602-A | Preparation method of chiral S/R-3-ethoxy-4-methoxy-alpha[(methylsulfonyl)methyl] benzyl alcohol | NAT UNIV DONG HWA | 2016-04-06 | — | — | CN | claimed |
| CN-105330586-A | Preparation method of Apremilast | NAT UNIV DONG HWA | 2016-02-17 | — | — | CN | claimed |
| CN-105461602-B | The preparation method of the chiral methoxyl group α of 3 ethyoxyl of S or R 4 [(mesyl) methyl] phenmethylol | 东华大学 | 2018-01-02 | — | — | CN | disclosed |
| CN-105330586-B | A kind of preparation method of Apremilast | 东华大学 | 2017-12-22 | — | — | CN | disclosed |
| CN-105461602-A | Preparation method of chiral S/R-3-ethoxy-4-methoxy-alpha[(methylsulfonyl)methyl] benzyl alcohol | NAT UNIV DONG HWA | 2016-04-06 | — | — | CN | disclosed |
| CN-105330586-A | Preparation method of Apremilast | NAT UNIV DONG HWA | 2016-02-17 | — | — | CN | disclosed |
| CN-104761474-A | Synthetic method of apremilast chiral amine intermediate | ENANTIOTECH CORP LTD | 2015-07-08 | — | — | CN | disclosed |