Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRB | P24530 | 10/20 | 0.44 |
| ▸ | EDNRA | P25101 | 10/20 | 0.44 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.44 |
| ▸ | KCNE1 | P15382 | 1/20 | 0.44 |
| ▸ | KCNQ1 | P51787 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.44 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | KCNN4 | O15554 | 1/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 2/20 | 0.39 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.39 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.38 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | TSHR | P16473 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12228351 | 1.00 | EDNRB (0.44) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL12228350 | 1.00 | EDNRB (0.44) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL18629954 | 0.86 | EDNRB (0.44) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL27905975 | 0.86 | EDNRB (0.44) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL2959625 | 0.86 | EDNRB (0.44) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL14254206 | 0.84 | EDNRB (0.41) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL11758268 | 0.80 | EDNRB (0.40) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL570658 | 0.79 | EDNRB (0.50) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL570417 | 0.79 | EDNRB (0.50) | EDNRBEDNRANR1I2KCNE1KCNQ1 | |
| SCHEMBL1067633 | 0.79 | EDNRB (0.50) | EDNRBEDNRANR1I2KCNE1KCNQ1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110437063-A | The preparation method of ambrisentan key intermediate | JIANGSU HANSOH PHARMACEUTICAL GROUP CO LTD | 2019-11-12 | — | — | CN | claimed |
| CN-108250151-A | A kind of preparation method of ambrisentan | 济南周行医药科技有限公司 | 2018-07-06 | — | — | CN | disclosed |
| CN-102952029-B | Method for resolving 2-hydroxyl-3-methoxy-3,3-diphenyl propionic acid racemate using amine derivative | BEIJING HOPE INTERNAT PHARMACEUTICAL TECHNOLOGY DEV CO LTD | 2015-07-08 | — | — | CN | disclosed |