Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.56 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.55 |
| ▸ | CYSLTR1 | Q9Y271 | 1/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | LMNA | P02545 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | POLB | P06746 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | BLM | P54132 | 1/20 | 0.50 |
| ▸ | TP53 | P04637 | 1/20 | 0.49 |
| ▸ | LOXL2 | Q9Y4K0 | 1/20 | 0.49 |
| ▸ | CYP4F2 | P78329 | 1/20 | 0.48 |
| ▸ | CYP4A11 | Q02928 | 1/20 | 0.48 |
| ▸ | VDR | P11473 | 1/20 | 0.47 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.47 |
| ▸ | NR1H4 | Q96RI1 | 1/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL26049008 | 0.86 | NR1H4 (0.60) | MRGPRX4KDM4ECYSLTR1SMN1; SMN2USP2 | |
| SCHEMBL7988758 | 0.85 | KDM4E (0.62) | MRGPRX4KDM4ECYSLTR1SMN1; SMN2USP2 | |
| SCHEMBL3239119 | 0.85 | MRGPRX4 (0.53) | MRGPRX4KDM4ECYSLTR1SMN1; SMN2NPC1 | |
| SCHEMBL17416724 | 0.85 | TDP1 (0.41) | MRGPRX4KDM4EL3MBTL1NR1H4 | |
| SCHEMBL24763747 | 0.84 | KDM4E (0.54) | MRGPRX4KDM4ECYSLTR1SMN1; SMN2USP2 | |
| SCHEMBL6780356 | 0.84 | KDM4E (0.54) | MRGPRX4KDM4ECYSLTR1SMN1; SMN2USP2 | |
| SCHEMBL2947246 | 0.83 | NR4A2 (0.59) | MRGPRX4CYSLTR1NPC1RAB9ANR1H4 | |
| SCHEMBL30281398 | 0.83 | NR4A2 (0.59) | MRGPRX4CYSLTR1NPC1RAB9ANR1H4 | |
| SCHEMBL27439509 | 0.83 | MRGPRX4 (0.59) | MRGPRX4KDM4ECYSLTR1SMN1; SMN2MAPK1 | |
| SCHEMBL14896697 | 0.82 | KDM4E (0.53) | MRGPRX4KDM4ECYSLTR1SMN1; SMN2USP2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104812755-A | Pyrazolopyridine derivatives as TTX-S blockers | RAQUALIA PHARMA INC | 2015-07-29 | — | — | CN | disclosed |