Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 4/20 | 0.54 |
| ▸ | TSHR | P16473 | 3/20 | 0.41 |
| ▸ | CYP3A4 | P08684 | 3/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | ALOX15 | P16050 | 2/20 | 0.41 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.41 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.41 |
| ▸ | CNR2 | P34972 | 2/20 | 0.40 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | LIPC | P11150 | 1/20 | 0.38 |
| ▸ | LIPG | Q9Y5X9 | 1/20 | 0.38 |
| ▸ | CNR1 | P21554 | 1/20 | 0.38 |
| ▸ | NPC1 | O15118 | 1/20 | 0.37 |
| ▸ | RAB9A | P51151 | 1/20 | 0.37 |
| ▸ | HPGD | P15428 | 1/20 | 0.37 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.37 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.37 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.37 |
| ▸ | STK4 | Q13043 | 1/20 | 0.37 |
| ▸ | STK3 | Q13188 | 1/20 | 0.37 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2578339 | 0.89 | PTGER4 (0.44) | PTGER4CYP3A4CNR2CNR1HDAC1 | |
| SCHEMBL16254681 | 0.85 | PTGER4 (0.40) | PTGER4TSHRCYP3A4ALDH1A1ALOX15 | |
| SCHEMBL15099940 | 0.80 | PTGER4 (0.44) | PTGER4TSHRCYP3A4ALDH1A1ALOX15 | |
| SCHEMBL9604228 | 0.79 | PTGER4 (0.58) | PTGER4CYP3A4ALDH1A1ALOX15SMN1; SMN2 | |
| SCHEMBL3133410 | 0.79 | PTGER4 (0.54) | PTGER4LIPCLIPGMAPT | |
| SCHEMBL8885032 | 0.79 | PTGER4 (0.43) | PTGER4TSHRCYP3A4ALDH1A1ALOX15 | |
| SCHEMBL11935246 | 0.79 | PTGER4 (0.47) | PTGER4CYP3A4ALDH1A1SMN1; SMN2CNR2 | |
| SCHEMBL13438926 | 0.79 | PTGER4 (0.47) | PTGER4CYP3A4ALDH1A1SMN1; SMN2CNR2 | |
| SCHEMBL27270334 | 0.77 | PTGER4 (0.55) | PTGER4TSHRCYP3A4ALDH1A1ALOX15 | |
| SCHEMBL7820003 | 0.76 | PTGER4 (0.54) | PTGER4CYP3A4ALDH1A1SMN1; SMN2TDP1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104854098-B | Benzimidazole derivatives as EP4 antagonists | 拜耳医药股份公司 | 2018-01-09 | — | — | CN | disclosed |
| CN-104854098-A | NOVEL BENZIMIDAZOLE DERIVATIVES AS EP4 ANTAGONISTS | Bayer Pharma AG | 2015-08-19 | — | — | CN | disclosed |