Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HPGD | P15428 | 3/20 | 0.56 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.56 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.38 |
| ▸ | GRM5 | P41594 | 1/20 | 0.37 |
| ▸ | NQO1 | P15559 | 1/20 | 0.34 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.34 |
| ▸ | RPS6KA5 | O75582 | 1/20 | 0.34 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.33 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.33 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.33 |
| ▸ | HCRTR2 | O43614 | 1/20 | 0.33 |
| ▸ | L3MBTL1 | Q9Y468 | 2/20 | 0.33 |
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.33 |
| ▸ | DHODH | Q02127 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27978326 | 0.80 | SMN1; SMN2 (0.56) | HPGDSMN1; SMN2LRRK2ALDH1A1GRM5 | |
| SCHEMBL18686677 | 0.79 | SMN1; SMN2 (0.37) | HPGDSMN1; SMN2LRRK2ALDH1A1GRM5 | |
| SCHEMBL16231386 | 0.79 | HPGD (0.50) | HPGDSMN1; SMN2LRRK2ALDH1A1GRM5 | |
| SCHEMBL4080885 | 0.78 | HPGD (0.63) | HPGDSMN1; SMN2LRRK2ALDH1A1GRM5 | |
| SCHEMBL16213742 | 0.77 | SMN1; SMN2 (0.53) | HPGDSMN1; SMN2LRRK2ALDH1A1KMT2A | |
| SCHEMBL22247426 | 0.77 | CNR2 (0.39) | HPGDSMN1; SMN2 | |
| SCHEMBL14117235 | 0.76 | HPGD (0.47) | HPGDSMN1; SMN2LRRK2ALDH1A1GRM5 | |
| SCHEMBL14853027 | 0.76 | HPGD (0.67) | HPGDSMN1; SMN2LRRK2ALDH1A1GRM5 | |
| SCHEMBL25411688 | 0.74 | LRRK2 (0.46) | HPGDSMN1; SMN2LRRK2ALDH1A1 | |
| SCHEMBL28718097 | 0.74 | HPGD (0.55) | HPGDSMN1; SMN2LRRK2ALDH1A1GRM5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-102791713-B | Imidazo [1,2-A ] pyrazine derivatives and their use for the prevention or treatment of neurological, psychiatric and metabolic disorders and diseases | JANSSEN PHARMACEUTICA N.V. (BE) | 2016-02-03 | — | — | CN | disclosed |
| CN-102596961-B | Imidazo [1,2-b] pyridazine derivatives and the purposes as PDE10 inhibitor thereof | JANSSEN PHARMACEUTICA N.V. (BE) | 2015-12-02 | — | — | CN | disclosed |