Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | C1R | P00736 | 7/20 | 0.41 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.36 |
| ▸ | MAPK10 | P53779 | 3/20 | 0.36 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.36 |
| ▸ | GAA | P10253 | 1/20 | 0.36 |
| ▸ | MAPT | P10636 | 1/20 | 0.36 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.36 |
| ▸ | IGF1R | P08069 | 2/20 | 0.34 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.33 |
| ▸ | MDM4 | O15151 | 1/20 | 0.33 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
| ▸ | MDM2 | Q00987 | 1/20 | 0.33 |
| ▸ | INSR | P06213 | 1/20 | 0.33 |
| ▸ | ALK | Q9UM73 | 1/20 | 0.33 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | GRIK1 | P39086 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13299024 | 0.80 | MAPK10 (0.45) | MAPK8MAPK10KDM4EGAAMAPT | |
| SCHEMBL691207 | 0.76 | FLT1 (0.45) | KDM4EGAAMAPTL3MBTL1IGF1R | |
| SCHEMBL693586 | 0.75 | PBRM1 (0.56) | MAPTKMT2A | |
| SCHEMBL1686520 | 0.73 | C1R (0.43) | C1RKDM4EGAAMAPTKMT2A | |
| SCHEMBL24752703 | 0.72 | ALK (0.44) | C1RMAPK10IGF1RINSRALK | |
| SCHEMBL30184233 | 0.72 | ALK (0.44) | C1RMAPK10IGF1RINSRALK | |
| SCHEMBL690590 | 0.72 | MAPK10 (0.65) | MAPK8MAPK10IGF1RMAPK3MAPK1 | |
| SCHEMBL29777593 | 0.72 | MAPK10 (0.65) | MAPK8MAPK10IGF1RMAPK3MAPK1 | |
| SCHEMBL28681862 | 0.71 | ALK (0.54) | IGF1RINSRALK | |
| SCHEMBL22858546 | 0.71 | EGFR (0.33) | MAPK8MAPK10MAPK3MAPK1ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105294759-A | Preparation method of antitumor drug | SOUTHEAST PHARMACEUTICALS CO LTD | 2016-02-03 | — | — | CN | disclosed |
| CN-105294759-A | Preparation method of antitumor drug | SOUTHEAST PHARMACEUTICALS CO LTD | 2016-02-03 | — | — | CN | disclosed |