Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE5A | O76074 | 2/20 | 0.40 |
| ▸ | ACP1 | P24666 | 1/20 | 0.38 |
| ▸ | KDM1A | O60341 | 1/20 | 0.37 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.37 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.37 |
| ▸ | CDK2 | P24941 | 1/20 | 0.37 |
| ▸ | GBA1 | P04062 | 2/20 | 0.36 |
| ▸ | GGPS1 | O95749 | 1/20 | 0.36 |
| ▸ | ADORA3 | P0DMS8 | 8/20 | 0.35 |
| ▸ | ADORA2A | P29274 | 4/20 | 0.35 |
| ▸ | ADORA1 | P30542 | 4/20 | 0.35 |
| ▸ | ADORA2B | P29275 | 2/20 | 0.34 |
| ▸ | CTNNB1 | P35222 | 1/20 | 0.34 |
| ▸ | TCF7L2 | Q9NQB0 | 1/20 | 0.34 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | MAPT | P10636 | 1/20 | 0.33 |
| ▸ | HTT | P42858 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2803611 | 1.00 | PDE5A (0.40) | PDE5AACP1KDM1ACCNE2CCNE1 | |
| SCHEMBL13283796 | 0.89 | PDE5A (0.42) | PDE5AKDM1ACCNE2CCNE1CDK2 | |
| SCHEMBL13283882 | 0.88 | CDK2 (0.49) | PDE5AKDM1ACCNE2CCNE1CDK2 | |
| SCHEMBL3702712 | 0.86 | PDE5A (0.58) | PDE5AKDM1ACCNE2CCNE1CDK2 | |
| SCHEMBL13283779 | 0.86 | PDE5A (0.45) | PDE5AKDM1ACCNE2CCNE1CDK2 | |
| SCHEMBL3702715 | 0.86 | PDE5A (0.58) | PDE5AKDM1ACCNE2CCNE1CDK2 | |
| SCHEMBL2806794 | 0.84 | NR1H4 (0.42) | PDE5AGBA1GGPS1ADORA3ADORA2A | |
| SCHEMBL3782095 | 0.82 | GBA1 (0.40) | PDE5AKDM1AGBA1ADORA2AADORA1 | |
| SCHEMBL2806792 | 0.82 | PDE5A (0.38) | PDE5AACP1KDM1ACCNE2CCNE1 | |
| SCHEMBL2806796 | 0.82 | PDE5A (0.38) | PDE5AACP1KDM1ACCNE2CCNE1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2241565-A1 | Aurora kinase inhibitors compounds | Universität Leipzig (DE) | 2010-10-20 | — | — | EP | claimed |
| EP-2241565-A1 | Aurora kinase inhibitors compounds | Universität Leipzig (DE) | 2010-10-20 | — | — | EP | disclosed |
| EP-2241565-A1 | Aurora kinase inhibitors compounds | Universität Leipzig (DE) | 2010-10-20 | — | — | EP | disclosed |
| WO-2010081881-A1 | AURORA KINASE INHIBITORS COMPOUNDS. | UNIVERSITÄT LEIPZIG (DE) | 2010-07-22 | — | — | WO | disclosed |
| WO-2010081881-A1 | AURORA KINASE INHIBITORS COMPOUNDS. | UNIVERSITÄT LEIPZIG (DE) | 2010-07-22 | — | — | WO | disclosed |