Benzene

Benzene

SCHEMBL28036071

COC(=O)C(F)(F)F.c1ccccc1

nearest known ligand 0.48

Full drug profile on Sugi Atlas →

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
KCNN4 O15554 1/20 0.48
SRC P12931 1/20 0.43
CTRB1 P17538 1/20 0.40
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
NPC1 O15118 1/20 0.39
MAPK1 P28482 1/20 0.39
RAB9A P51151 1/20 0.39
MAPT P10636 1/20 0.38
CES1 P23141 2/20 0.38
CES2 O00748 1/20 0.38
ACHE P22303 1/20 0.38
GAA P10253 1/20 0.38
L3MBTL1 Q9Y468 1/20 0.38
TSHR P16473 1/20 0.37
DGAT1 O75907 1/20 0.37
ALDH1A1 P00352 2/20 0.36
ELANE P08246 1/20 0.35
CYP1A2 P05177 1/20 0.34
CYP3A4 P08684 1/20 0.34

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL111507 0.91
Trifluoroacetic Acid SCHEMBL28075338 0.89 KCNN4 (0.38) KCNN4SRCCTRB1MEN1KMT2A
Benzene SCHEMBL27965223 0.89 FFAR3 (0.43) KCNN4SRCCTRB1MEN1KMT2A
SCHEMBL28010803 0.88
Water SCHEMBL27540049 0.88
Methane SCHEMBL16334296 0.88
Hydrochloric Acid SCHEMBL28021257 0.88
Ammonia Solution, Strong SCHEMBL6194945 0.88
Pyridine SCHEMBL5316497 0.87 KCNN4 (0.39) KCNN4SRCCTRB1MEN1KMT2A
Isobutane SCHEMBL19205551 0.84 KCNN4 (0.35) KCNN4SRCCTRB1MEN1KMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105026360-B S1P conditioning agents 比奥根MA公司 2017-08-25 CN disclosed
CN-105026360-A S1P modulating agents BIOGEN IDEC INC 2015-11-04 CN disclosed