SCHEMBL28036348

SCHEMBL28036348

O[C@H](CBr)c1ccc(Cl)cc1

nearest known ligand 0.52

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
AOC3 Q16853 1/20 0.52
TSHR P16473 2/20 0.41
MAPK1 P28482 2/20 0.41
HIF1A Q16665 2/20 0.41
TDP1 Q9NUW8 2/20 0.41
SLC6A2 P23975 1/20 0.41
SLC6A4 P31645 1/20 0.41
SLC6A3 Q01959 1/20 0.41
GSK3B P49841 1/20 0.40
GAA P10253 1/20 0.40
GABBR2 O75899 1/20 0.40
GABBR1 Q9UBS5 1/20 0.40
LMNA P02545 4/20 0.39
TP53 P04637 1/20 0.39
HPGD P15428 1/20 0.39
ADRB2 P07550 1/20 0.39
HTR1A P08908 1/20 0.39
IDO1 P14902 2/20 0.38
CYP2A6 P11509 1/20 0.38
SMN1; SMN2 Q16637 1/20 0.38

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6280792 1.00 AOC3 (0.52) AOC3TSHRMAPK1HIF1ATDP1
SCHEMBL7779197 1.00 AOC3 (0.52) AOC3TSHRMAPK1HIF1ATDP1
SCHEMBL11860066 0.82 AOC3 (0.48) AOC3TSHRMAPK1HIF1ATDP1
SCHEMBL21353865 0.81 AOC3 (0.44) AOC3TSHRMAPK1HIF1ATDP1
SCHEMBL21353864 0.81 AOC3 (0.44) AOC3TSHRMAPK1HIF1ATDP1
SCHEMBL21393441 0.80 AOC3 (0.47) AOC3TSHRMAPK1HIF1ATDP1
SCHEMBL29700206 0.80 AOC3 (0.55) AOC3TSHRMAPK1HIF1ATDP1
SCHEMBL21363396 0.80 AOC3 (0.47) AOC3SLC6A2SLC6A4SLC6A3GAA
SCHEMBL5437078 0.78 AOC3 (0.53) AOC3TSHRMAPK1HIF1ATDP1
SCHEMBL1155443 0.78 AOC3 (0.53) AOC3TSHRMAPK1HIF1ATDP1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-104961626-B A kind of preparation method of hydroxyl bromine compounds 中国科学院化学研究所 2016-09-21 CN disclosed
CN-104961626-A Hydroxyl bromine compound preparation method CHINESE ACAD INST CHEMISTRY 2015-10-07 CN disclosed