Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | COMT | P21964 | 1/20 | 0.32 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.31 |
| ▸ | HSP90AB1 | P08238 | 1/20 | 0.31 |
| ▸ | JAK3 | P52333 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL25164736 | 0.98 | KDM5B (0.35) | KDM5BKDM4ECOMTHSP90AA1HSP90AB1 | |
| SCHEMBL28270253 | 0.80 | KDM5B (0.35) | KDM5BKDM4ECOMTHSP90AA1HSP90AB1 | |
| SCHEMBL15065749 | 0.78 | HSP90AA1 (0.39) | KDM5BKDM4ECOMTHSP90AA1HSP90AB1 | |
| SCHEMBL12775458 | 0.77 | JAK3 (0.32) | JAK3 | |
| SCHEMBL25301572 | 0.77 | KDM5B (0.33) | KDM5BKDM4ECOMTHSP90AA1HSP90AB1 | |
| SCHEMBL18031208 | 0.77 | KDM4E (0.37) | KDM4ECOMTHSP90AA1HSP90AB1 | |
| Ammonia Solution, Strong SCHEMBL29243623 | 0.76 | HTT (0.36) | KDM4E | |
| SCHEMBL9473876 | 0.76 | JAK3 (0.34) | JAK3 | |
| SCHEMBL25163410 | 0.74 | KDM4E (0.36) | KDM5BKDM4E | |
| SCHEMBL26783154 | 0.72 | HSP90AA1 (0.38) | KDM5BKDM4ECOMTHSP90AA1HSP90AB1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105061326-A | Pyridazinone derivatives as well as preparation method and application thereof | SICHUAN BAILI PHARMACEUTICAL CO LTD | 2015-11-18 | — | — | CN | disclosed |