SCHEMBL28038639

SCHEMBL28038639

CS(=O)(=O)[CH]c1ccncc1-c1ccccn1

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
CYP2A6 P11509 1/20 0.42
CYP46A1 Q9Y6A2 2/20 0.39
MAOA P21397 1/20 0.38
MAOB P27338 1/20 0.38
METAP1 P53582 2/20 0.37
KDM4E B2RXH2 1/20 0.37
LMNA P02545 1/20 0.37
CYP1A2 P05177 1/20 0.37
POLB P06746 1/20 0.37
CCR1 P32246 1/20 0.37
CCR5 P51681 1/20 0.37
CCR8 P51685 1/20 0.37
BLM P54132 1/20 0.37
HIF1A Q16665 1/20 0.37
DOHH Q9BU89 1/20 0.37
P4HTM Q9NXG6 1/20 0.37
EDNRA P25101 1/20 0.37
PTGS1 P23219 1/20 0.37
PTGS2 P35354 1/20 0.37
BRD4 O60885 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28038581 0.88 CYP2A6 (0.42) CYP2A6CYP46A1MAOAMAOBMETAP1
SCHEMBL28038210 0.76 SLC22A12 (0.41) MAOAMAOBPTGS1PTGS2PIK3CD
SCHEMBL1271442 0.73 CYP2A6 (0.42) CYP2A6CYP46A1MAOAMAOBMETAP1
SCHEMBL1273291 0.71 CYP2A6 (0.41) CYP2A6CYP46A1MAOAMAOBMETAP1
SCHEMBL5142866 0.71 CYP2A6 (0.48) CYP2A6METAP1KDM4ELMNACYP1A2
SCHEMBL1272639 0.71 CYP2A6 (0.42) CYP2A6CYP46A1MAOAMAOBMETAP1
SCHEMBL1272845 0.69 CYP2A6 (0.41) CYP2A6CYP46A1MAOAMAOBMETAP1
SCHEMBL12854083 0.69 KDM4E (0.50) CYP2A6CYP46A1MAOAMAOBMETAP1
SCHEMBL1271441 0.68 CYP2A6 (0.42) CYP2A6CYP46A1MAOAMAOBMETAP1
SCHEMBL23598623 0.67 CYP2A6 (0.48) CYP2A6MAOAMAOBMETAP1KDM4E

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101180266-B As the alpha ketoamide compounds of cystatin Vero Bay (US) 2015-11-25 CN disclosed