Sugi Predict

Sugi Predict / Compounds / SCHEMBL2803873

SCHEMBL2803873

SCHEMBL2803873

COc1ccc2[nH]c(CNc3ncc4c(n3)-c3ccccc3C(c3ccccc3Cl)C4)cc2c1

nearest known ligand 0.40

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 2/20 0.40
▸ FGFR2 P21802 2/20 0.40
▸ CSF1R P07333 1/20 0.40
▸ FGFR3 P22607 1/20 0.40
▸ MAOA P21397 2/20 0.37
▸ MAOB P27338 2/20 0.37
▸ KDR P35968 3/20 0.37
▸ LOXL2 Q9Y4K0 1/20 0.36
▸ HRH3 Q9Y5N1 1/20 0.36
▸ ALDH1A1 P00352 3/20 0.35
▸ MAPT P10636 2/20 0.35
▸ KDM4E B2RXH2 2/20 0.35
▸ OPRK1 P41145 1/20 0.35
▸ USP2 O75604 2/20 0.35
▸ LMNA P02545 2/20 0.35
▸ CYP1A2 P05177 2/20 0.35
▸ CYP3A4 P08684 2/20 0.35
▸ CYP2D6 P10635 2/20 0.35
▸ CYP2C9 P11712 2/20 0.35
▸ MAPK1 P28482 2/20 0.35

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2803855 0.90 FGFR1 (0.46) FGFR1FGFR2CSF1RFGFR3MAOA
SCHEMBL2805624 0.83 FGFR1 (0.44) FGFR1FGFR2CSF1RFGFR3KDR
SCHEMBL2806363 0.79 FGFR1 (0.48) FGFR1FGFR2CSF1RFGFR3KDR
SCHEMBL2803877 0.78 FGFR1 (0.45) FGFR1FGFR2CSF1RFGFR3KDR
SCHEMBL2808397 0.78 CYP1A2 (0.47) FGFR1FGFR2CSF1RFGFR3ALDH1A1
SCHEMBL2803090 0.77 FGFR1 (0.54) FGFR1FGFR2CSF1RFGFR3ALDH1A1
SCHEMBL2804043 0.76 FGFR1 (0.47) FGFR1FGFR2CSF1RFGFR3KDR
SCHEMBL2803823 0.75 KDR (0.49) FGFR1FGFR2CSF1RFGFR3KDR
SCHEMBL2804022 0.75 FGFR1 (0.43) FGFR1FGFR2CSF1RFGFR3KDR
SCHEMBL2806906 0.75 CSF1R (0.51) FGFR1FGFR2CSF1RFGFR3KDR

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2379506-B1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS ARQULE INC (US) 2015-09-02 — — EP disclosed
EP-2379506-B1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS ARQULE INC (US) 2015-09-02 — — EP disclosed
US-8357694-B2 Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds ARQULE, INC. (US) 2013-01-22 — — US disclosed
US-8357694-B2 Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds ARQULE, INC. (US) 2013-01-22 — — US disclosed
US-8357694-B2 Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds ARQULE, INC. (US) 2013-01-22 — — US disclosed
US-20100239525-A1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS ARQULE, INC. (US) 2010-09-23 — — US disclosed
US-20100239525-A1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS ARQULE, INC. (US) 2010-09-23 — — US disclosed
WO-2010078421-A1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS ARQULE, INC. (US) 2010-07-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100239525-A1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS NQO1, DPYD, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 FGFR1 530/4885FGFR2 511/4885CSF1R 4606/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.