Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.54 |
| ▸ | JAK1 | P23458 | 7/20 | 0.54 |
| ▸ | TYK2 | P29597 | 7/20 | 0.54 |
| ▸ | JAK3 | P52333 | 7/20 | 0.54 |
| ▸ | BTK | Q06187 | 6/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27997777 | 0.84 | JAK2 (0.71) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL27998021 | 0.81 | JAK2 (0.61) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL27998017 | 0.81 | JAK2 (0.50) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL15995152 | 0.79 | JAK2 (0.56) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL28258694 | 0.79 | MAPK10 (0.45) | JAK2JAK1TYK2JAK3POLB | |
| SCHEMBL28816460 | 0.79 | JAK2 (0.53) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL148196 | 0.75 | JAK2 (0.58) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL27997807 | 0.75 | JAK2 (0.59) | JAK2JAK1TYK2JAK3BTK | |
| SCHEMBL148776 | 0.74 | JAK2 (0.53) | JAK2JAK1TYK2JAK3 | |
| SCHEMBL27997819 | 0.73 | JAK2 (0.60) | JAK2JAK1TYK2JAK3BTK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105008352-B | Carbazole compounds useful as bromodomain inhibitors | 百时美施贵宝公司 | 2018-12-07 | — | — | CN | disclosed |
| CN-105008352-A | Carbazole compounds useful as bromodomain inhibitors | BRISTOL MYERS SQUIBB CO | 2015-10-28 | — | — | CN | disclosed |