Sugi Predict

Sugi Predict / Compounds / SCHEMBL2804030

SCHEMBL2804030

SCHEMBL2804030

FC(F)(F)c1ccc(CNc2ncc3c(n2)-c2ccccc2C(c2ccccc2)C3)cc1

nearest known ligand 0.54

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 2/20 0.54
▸ FGFR2 P21802 2/20 0.54
▸ USP1 O94782 3/20 0.43
▸ WDR48 Q8TAF3 3/20 0.43
▸ APP P05067 2/20 0.43
▸ MERTK Q12866 1/20 0.42
▸ KDM1A O60341 1/20 0.40
▸ MAOA P21397 1/20 0.40
▸ MAOB P27338 1/20 0.40
▸ ACHE P22303 1/20 0.40
▸ CSF1R P07333 1/20 0.40
▸ FGFR3 P22607 1/20 0.40
▸ HDAC6 Q9UBN7 2/20 0.39
▸ HDAC3 O15379 1/20 0.39
▸ HDAC1 Q13547 1/20 0.39
▸ HDAC2 Q92769 1/20 0.39
▸ VNN1 O95497 2/20 0.38
▸ CCNT1 O60563 1/20 0.37
▸ HDAC4 P56524 1/20 0.37
▸ HTR2A P28223 2/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2802239 0.93 FGFR1 (0.46) FGFR1FGFR2USP1WDR48APP
SCHEMBL2806866 0.89 FGFR1 (0.51) FGFR1FGFR2USP1WDR48APP
SCHEMBL13126143 0.88 FGFR1 (0.41) FGFR1FGFR2USP1WDR48APP
SCHEMBL2804389 0.85 FGFR1 (0.54) FGFR1FGFR2USP1WDR48MERTK
SCHEMBL2803281 0.82 FGFR1 (0.54) FGFR1FGFR2USP1WDR48APP
SCHEMBL2803026 0.82 FGFR1 (0.56) FGFR1FGFR2MERTKKDM1AMAOA
SCHEMBL2803237 0.80 FGFR1 (0.52) FGFR1FGFR2APPKDM1AMAOA
SCHEMBL2808244 0.80 FGFR1 (0.59) FGFR1FGFR2APPMERTKCSF1R
SCHEMBL2803933 0.80 FGFR1 (0.57) FGFR1FGFR2MERTKCSF1RFGFR3
SCHEMBL2807834 0.79 FGFR1 (0.58) FGFR1FGFR2KDM1AMAOAMAOB

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2379506-B1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS ARQULE INC (US) 2015-09-02 — — EP disclosed
EP-2379506-B1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS ARQULE INC (US) 2015-09-02 — — EP disclosed
US-8357694-B2 Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds ARQULE, INC. (US) 2013-01-22 — — US disclosed
US-8357694-B2 Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds ARQULE, INC. (US) 2013-01-22 — — US disclosed
US-8357694-B2 Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds ARQULE, INC. (US) 2013-01-22 — — US disclosed
US-20100239525-A1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS ARQULE, INC. (US) 2010-09-23 — — US disclosed
US-20100239525-A1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS ARQULE, INC. (US) 2010-09-23 — — US disclosed
WO-2010078421-A1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS ARQULE, INC. (US) 2010-07-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100239525-A1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS NQO1, DPYD, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 FGFR1 530/4885FGFR2 511/4885USP1 4801/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.