SCHEMBL28040333

SCHEMBL28040333

Cc1ccc(O[SiH](C)C)c(N=Cc2cnccn2)c1.[H+]

nearest known ligand 0.35

Predicted protein targets (top 5)

geneUniProtsupporting neighboursconfidence
KDM4E B2RXH2 2/20 0.35
CTH P32929 1/20 0.32
LMNA P02545 1/20 0.31
MAPT P10636 1/20 0.31
HTT P42858 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL17499634 0.99 KDM4E (0.36) KDM4ECTHLMNAMAPTHTT
SCHEMBL28040282 0.90 KDM4E (0.33) KDM4ECTH
SCHEMBL17499392 0.89 KDM4E (0.33) KDM4ECTH
SCHEMBL16097484 0.85 KDM4E (0.45) KDM4ECTHLMNAMAPTHTT
SCHEMBL16097485 0.85 KDM4E (0.45) KDM4ECTHLMNAMAPTHTT
SCHEMBL28040283 0.84 NR4A1 (0.43) KDM4ELMNAMAPTHTT
SCHEMBL16097217 0.82 NR4A1 (0.44) KDM4ELMNAMAPTHTT
SCHEMBL16096332 0.82 KDM4E (0.36) KDM4ECTHLMNAMAPTHTT
SCHEMBL16096331 0.82 KDM4E (0.36) KDM4ECTHLMNAMAPTHTT
SCHEMBL17499207 0.82 KDM4E (0.35) KDM4ECTHLMNAMAPT

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105209268-A Heterocyclic imine functionalized polymers BRIDGESTONE CORP 2015-12-30 CN disclosed