Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | FGFR1 | P11362 | 3/20 | 0.73 |
| ▸ | FGFR2 | P21802 | 2/20 | 0.73 |
| ▸ | CSF1R | P07333 | 1/20 | 0.73 |
| ▸ | FGFR3 | P22607 | 1/20 | 0.73 |
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 9/20 | 0.42 |
| ▸ | CDK9 | P50750 | 8/20 | 0.42 |
| ▸ | KDR | P35968 | 5/20 | 0.41 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.40 |
| ▸ | CDK5R1 | Q15078 | 1/20 | 0.40 |
| ▸ | PLK1 | P53350 | 3/20 | 0.40 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.39 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.38 |
| ▸ | KIT | P10721 | 1/20 | 0.38 |
| ▸ | FLT3 | P36888 | 1/20 | 0.38 |
| ▸ | PLK3 | Q9H4B4 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2804274 | 1.00 | FGFR1 (0.73) | FGFR1FGFR2CSF1RFGFR3SYK | |
| SCHEMBL28343975 | 0.95 | CSF1R (0.69) | FGFR1FGFR2CSF1RFGFR3SYK | |
| SCHEMBL28343974 | 0.95 | CSF1R (0.69) | FGFR1FGFR2CSF1RFGFR3SYK | |
| SCHEMBL2805735 | 0.93 | FGFR1 (0.70) | FGFR1FGFR2CSF1RFGFR3SYK | |
| SCHEMBL2805734 | 0.93 | FGFR1 (0.70) | FGFR1FGFR2CSF1RFGFR3SYK | |
| SCHEMBL19000832 | 0.91 | FGFR1 (0.76) | FGFR1FGFR2CSF1RFGFR3SYK | |
| SCHEMBL2803995 | 0.91 | FGFR1 (0.61) | FGFR1FGFR2CSF1RFGFR3CDK2 | |
| SCHEMBL19012094 | 0.88 | FGFR1 (0.86) | FGFR1FGFR2CSF1RFGFR3SYK | |
| SCHEMBL2489266 | 0.88 | FGFR1 (0.60) | FGFR1FGFR2CSF1RFGFR3SYK | |
| SCHEMBL2489267 | 0.88 | FGFR1 (0.60) | FGFR1FGFR2CSF1RFGFR3SYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 14 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-3189036-B1 | COMPOSITIONS AND METHODS FOR TREATING PROLIFERATION DISORDERS | ARQULE INC (US) | 2023-07-19 | — | — | EP | disclosed |
| EP-4015508-A1 | METHODS FOR PREPARING SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE | ArQule, Inc. (US) | 2022-06-22 | — | — | EP | disclosed |
| CN-111494378-A | Compositions and methods for treating proliferative disorders | 艾科尔公司 | 2020-08-07 | — | — | CN | disclosed |
| CN-107074769-B | Compositions and methods for treating proliferative disorders | 艾科尔公司 | 2020-04-07 | — | — | CN | disclosed |
| CN-110669015-A | Preparation method of FGFR inhibitor | 上海喀露蓝科技有限公司 | 2020-01-10 | — | — | CN | disclosed |
| US-9949981-B2 | Compositions and methods for treating proliferation disorders | ARQULE, INC. (US) | 2018-04-24 | — | — | US | disclosed |
| EP-3189036-A1 | COMPOSITIONS AND METHODS FOR TREATING PROLIFERATION DISORDERS | ArQule, Inc. (US) | 2017-07-12 | — | — | EP | disclosed |
| US-20160067260-A1 | Compositions and Methods for Treating Proliferation Disorders | ARQULE, INC. | 2016-03-10 | — | — | US | disclosed |
| WO-2016037044-A1 | COMPOSITIONS AND METHODS FOR TREATING PROLIFERATION DISORDERS | ARQULE, INC. (US) | 2016-03-10 | — | — | WO | disclosed |
| EP-2379506-B1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE INC (US) | 2015-09-02 | — | — | EP | disclosed |
| US-8357694-B2 | Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds | ARQULE, INC. (US) | 2013-01-22 | — | — | US | disclosed |
| US-8357694-B2 | Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds | ARQULE, INC. (US) | 2013-01-22 | — | — | US | disclosed |
| US-8357694-B2 | Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds | ARQULE, INC. (US) | 2013-01-22 | — | — | US | disclosed |
| US-20100239525-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS | ARQULE, INC. (US) | 2010-09-23 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20160067260-A1 | Compositions and Methods for Treating Proliferation Disorders | MKI67, HRAS, VHL | FGFR1 3125/4885FGFR2 3050/4885CSF1R 4162/4885 |
| US-20100239525-A1 | SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS | NQO1, DPYD, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 | FGFR1 530/4885FGFR2 511/4885CSF1R 4606/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.