Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.62 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.44 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.44 |
| ▸ | CHRNB2 | P17787 | 1/20 | 0.40 |
| ▸ | CHRNA4 | P43681 | 1/20 | 0.40 |
| ▸ | TDO2 | P48775 | 2/20 | 0.35 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.35 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.35 |
| ▸ | RAB9A | P51151 | 1/20 | 0.34 |
| ▸ | NISCH | Q9Y2I1 | 1/20 | 0.33 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Quinazoline SCHEMBL27875528 | 0.90 | EGFR (0.77) | EGFRPIK3CDPIK3CACHRNB2CHRNA4 | |
| Quinazoline SCHEMBL1337802 | 0.90 | EGFR (0.77) | EGFRPIK3CDPIK3CATDO2PDGFRB | |
| Quinazoline SCHEMBL29144630 | 0.87 | EGFR (0.71) | EGFRPIK3CDPIK3CACHRNB2CHRNA4 | |
| Quinazoline SCHEMBL6569237 | 0.85 | EGFR (0.69) | EGFRPIK3CDPIK3CACHRNB2CHRNA4 | |
| Quinazoline SCHEMBL16444698 | 0.83 | EGFR (0.77) | EGFRPIK3CDPIK3CACHRNB2CHRNA4 | |
| Quinazoline SCHEMBL3686138 | 0.83 | EGFR (0.77) | EGFRPIK3CDPIK3CACHRNB2CHRNA4 | |
| Quinazoline SCHEMBL29902476 | 0.80 | EGFR (0.77) | EGFRPIK3CDPIK3CATDO2PDGFRB | |
| Quinazoline SCHEMBL5438273 | 0.80 | EGFR (0.77) | EGFRPIK3CDPIK3CATDO2PDGFRB | |
| Quinazoline SCHEMBL27407620 | 0.79 | EGFR (0.91) | EGFRPIK3CDPIK3CATDO2PDGFRB | |
| Quinazoline SCHEMBL29490398 | 0.79 | EGFR (1.00) | EGFRPIK3CDPIK3CATDO2PDGFRB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105939717-B | Methods of treating and preventing alloantibody-driven chronic graft-versus-host disease | 药品循环有限责任公司 | 2019-09-13 | — | — | CN | disclosed |
| CN-105939717-A | Methods of treating and preventing alloantibody-driven chronic graft-versus-host disease | 药品循环有限责任公司 | 2016-09-14 | — | — | CN | disclosed |
| CN-104994858-A | TEC family kinase inhibitor adjuvant therapy | PHARMACYCLICS INC | 2015-10-21 | — | — | CN | disclosed |