Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ADORA2A | P29274 | 17/20 | 0.50 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.50 |
| ▸ | ADORA2B | P29275 | 1/20 | 0.50 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.50 |
| ▸ | LMNA | P02545 | 1/20 | 0.37 |
| ▸ | HTT | P42858 | 1/20 | 0.37 |
| ▸ | PDE10A | Q9Y233 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | HPGD | P15428 | 1/20 | 0.34 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.34 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2549250 | 0.83 | ADORA2A (0.56) | ADORA2AADORA3ADORA2BADORA1LMNA | |
| SCHEMBL29800890 | 0.80 | ADORA2A (0.41) | ADORA2AADORA3ADORA2BADORA1LMNA | |
| SCHEMBL2553742 | 0.80 | ADORA2A (0.58) | ADORA2AADORA3ADORA2BADORA1LMNA | |
| SCHEMBL28042501 | 0.77 | PDE10A (0.46) | ADORA2AADORA1LMNAPDE10AKDM4E | |
| SCHEMBL29800865 | 0.75 | ADORA2A (0.40) | ADORA2AADORA3ADORA2BADORA1 | |
| SCHEMBL15905323 | 0.75 | ADORA2A (0.64) | ADORA2AADORA3ADORA2BADORA1PDE10A | |
| SCHEMBL2550277 | 0.74 | ADORA2A (0.62) | ADORA2AADORA3ADORA2BADORA1LMNA | |
| SCHEMBL2550404 | 0.73 | ADORA2A (0.53) | ADORA2AADORA3ADORA2BADORA1LMNA | |
| SCHEMBL2547816 | 0.72 | ADORA2A (0.80) | ADORA2AADORA3ADORA2BADORA1LMNA | |
| SCHEMBL2541912 | 0.72 | ADORA2A (0.59) | ADORA2AADORA3ADORA2BADORA1LMNA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105008346-A | Novel pyrimidine derivatives as phosphodiesterase 10(PDE-10) inhibitors | PALOBIOFARMA SL | 2015-10-28 | — | — | CN | claimed |
| CN-105008346-A | Novel pyrimidine derivatives as phosphodiesterase 10(PDE-10) inhibitors | PALOBIOFARMA SL | 2015-10-28 | — | — | CN | disclosed |