Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Fluvastatin. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR known ✓ | P04035 | 8/20 | 0.90 |
| ▸ | CYP2C9 | P11712 | 4/20 | 0.90 |
| ▸ | SIRT6 | Q8N6T7 | 2/20 | 0.90 |
| ▸ | TBXA2R | P21731 | 2/20 | 0.90 |
| ▸ | ADRA1A | P35348 | 2/20 | 0.90 |
| ▸ | NR4A2 | P43354 | 2/20 | 0.90 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.90 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.90 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.90 |
| ▸ | PGR | P06401 | 1/20 | 0.90 |
| ▸ | ADORA3 | P0DMS8 | 1/20 | 0.90 |
| ▸ | RXRA | P19793 | 1/20 | 0.90 |
| ▸ | CCKAR | P32238 | 1/20 | 0.90 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.90 |
| ▸ | SLC10A1 | Q14973 | 1/20 | 0.90 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.76 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.76 |
| ▸ | LMNA | P02545 | 1/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.76 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.76 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Fluvastatin SCHEMBL28043000 | 0.95 | HMGCR (0.96) | HMGCRCYP2C9SIRT6TBXA2RADRA1A | |
| Fluvastatin SCHEMBL556754 | 0.95 | HMGCR (1.00) | HMGCRCYP2C9SIRT6TBXA2RADRA1A | |
| Fluvastatin SCHEMBL678274 | 0.95 | HMGCR (1.00) | HMGCRCYP2C9SIRT6TBXA2RADRA1A | |
| Fluvastatin SCHEMBL4295454 | 0.95 | HMGCR (1.00) | HMGCRCYP2C9SIRT6TBXA2RADRA1A | |
| Fluvastatin SCHEMBL628757 | 0.95 | HMGCR (1.00) | HMGCRCYP2C9SIRT6TBXA2RADRA1A | |
| Fluvastatin SCHEMBL23468028 | 0.95 | HMGCR (1.00) | HMGCRCYP2C9SIRT6TBXA2RADRA1A | |
| Fluvastatin SCHEMBL2848 | 0.95 | HMGCR (1.00) | HMGCRCYP2C9SIRT6TBXA2RADRA1A | |
| Fluvastatin SCHEMBL13501651 | 0.95 | HMGCR (1.00) | HMGCRCYP2C9SIRT6TBXA2RADRA1A | |
| Fluvastatin SCHEMBL2849 | 0.95 | HMGCR (1.00) | HMGCRCYP2C9SIRT6TBXA2RADRA1A | |
| Fluvastatin SCHEMBL6268460 | 0.95 | HMGCR (1.00) | HMGCRCYP2C9SIRT6TBXA2RADRA1A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105017231-B | Polysubstituted fluorine-containing trim of indoles statin and application thereof | 上海应用技术学院 | 2018-01-26 | — | — | CN | disclosed |
| CN-105017231-A | Polysubstituted indole statin fluorine-containing modifier and use thereof | SHANGHAI INST TECHNOLOGY | 2015-11-04 | — | — | CN | disclosed |