Sugi Predict

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SCHEMBL2804360

SCHEMBL2804360

CN(C)CCCNc1ncc2c(n1)-c1ccccc1C(c1ccc(Cl)c(Cl)c1)C2

nearest known ligand 0.51

Predicted protein targets (top 12)

geneUniProtsupporting neighboursconfidence
▸ FGFR1 P11362 3/20 0.41
▸ FGFR2 P21802 2/20 0.41
▸ SLC6A2 P23975 13/20 0.41
▸ SLC6A4 P31645 13/20 0.41
▸ SLC6A3 Q01959 13/20 0.41
▸ CSF1R P07333 1/20 0.39
▸ FGFR3 P22607 1/20 0.39
▸ ADORA1 P30542 2/20 0.38
▸ CYP2D6 P10635 3/20 0.37
▸ CYP2C19 P33261 3/20 0.37
▸ KCNH2 Q12809 2/20 0.37
▸ CYP3A4 P08684 1/20 0.37

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2805097 1.00 FGFR1 (0.41) FGFR1FGFR2SLC6A2SLC6A4SLC6A3
SCHEMBL2805037 1.00 FGFR1 (0.41) FGFR1FGFR2SLC6A2SLC6A4SLC6A3
SCHEMBL2805906 0.97 FGFR1 (0.41) FGFR1FGFR2SLC6A2SLC6A4SLC6A3
SCHEMBL2804763 0.97 FGFR1 (0.41) FGFR1FGFR2SLC6A2SLC6A4SLC6A3
SCHEMBL2803083 0.97 FGFR1 (0.41) FGFR1FGFR2SLC6A2SLC6A4SLC6A3
SCHEMBL2802869 0.96 FGFR1 (0.40) FGFR1FGFR2SLC6A2SLC6A4SLC6A3
SCHEMBL2802231 0.96 FGFR1 (0.40) FGFR1FGFR2SLC6A2SLC6A4SLC6A3
SCHEMBL2805027 0.90 FGFR1 (0.46) FGFR1FGFR2CSF1RFGFR3ADORA1
SCHEMBL2802801 0.89 FGFR1 (0.43) FGFR1FGFR2SLC6A4FGFR3
SCHEMBL2806766 0.88 FGFR1 (0.41) FGFR1FGFR2CSF1RFGFR3ADORA1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2379506-B1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS ARQULE INC (US) 2015-09-02 — — EP disclosed
EP-2379506-B1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS ARQULE INC (US) 2015-09-02 — — EP disclosed
US-8357694-B2 Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds ARQULE, INC. (US) 2013-01-22 — — US disclosed
US-8357694-B2 Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds ARQULE, INC. (US) 2013-01-22 — — US disclosed
US-8357694-B2 Substituted 5,6-dihydro-6-phenylbenzo[F]isoquinolin-2-amine compounds ARQULE, INC. (US) 2013-01-22 — — US disclosed
US-20100239525-A1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS ARQULE, INC. (US) 2010-09-23 — — US disclosed
US-20100239525-A1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS ARQULE, INC. (US) 2010-09-23 — — US disclosed
WO-2010078421-A1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F] ISOQUINOLIN-2-AMINE COMPOUNDS ARQULE, INC. (US) 2010-07-08 — — WO disclosed

Patent text — is the patent's own abstract consistent with the prediction?

For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.

PatentTitleText reads most aboutPredicted target · text-rank
US-20100239525-A1 SUBSTITUTED 5,6-DIHYDRO-6-PHENYLBENZO[F]ISOQUINOLIN-2-AMINE COMPOUNDS NQO1, DPYD, H4C1; H4C2; H4C3; H4C4; H4C5; H4C6; H4C8; H4C9; H4C11; H4C12; H4C13; H4C14; H4C15; H4C16 FGFR1 530/4885FGFR2 511/4885SLC6A2 233/4885

“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.