Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CRBN | Q96SW2 | 5/20 | 0.69 |
| ▸ | NPC1 | O15118 | 1/20 | 0.36 |
| ▸ | MAPK13 | O15264 | 1/20 | 0.36 |
| ▸ | MAPK12 | P53778 | 1/20 | 0.36 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.36 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.36 |
| ▸ | ITGB3 | P05106 | 1/20 | 0.33 |
| ▸ | ITGB1 | P05556 | 1/20 | 0.33 |
| ▸ | ITGAV | P06756 | 1/20 | 0.33 |
| ▸ | ITGA4 | P13612 | 1/20 | 0.33 |
| ▸ | CA9 | Q16790 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Succinimide SCHEMBL28922106 | 0.89 | CRBN (0.55) | CRBNNPC1MAPK13MAPK12MAPK11 | |
| Formic Acid SCHEMBL29113973 | 0.88 | CRBN (0.72) | CRBNITGB3ITGB1ITGAVITGA4 | |
| Formic Acid SCHEMBL30727529 | 0.88 | CRBN (0.72) | CRBNITGB3ITGB1ITGAVITGA4 | |
| Succinimide SCHEMBL1600526 | 0.83 | — | — | |
| Succinimide SCHEMBL1326078 | 0.83 | CRBN (1.00) | CRBNNPC1MAPK13MAPK12MAPK11 | |
| Succinimide SCHEMBL774 | 0.83 | — | — | |
| Succinimide SCHEMBL1466558 | 0.83 | — | — | |
| Succinimide SCHEMBL8361206 | 0.83 | CRBN (1.00) | CRBNNPC1MAPK13MAPK12MAPK11 | |
| Succinimide SCHEMBL10709037 | 0.79 | — | — | |
| Succinimide SCHEMBL9336599 | 0.79 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-4288442-A1 | UBIQUITIN-SPECIFIC PROTEASE 7 (USP7) INHIBITORS AND USES THEREOF | Faxian Therapeutics, LLC (US) | 2023-12-13 | — | — | EP | disclosed |
| WO-2022170198-A1 | UBIQUITIN-SPECIFIC PROTEASE 7 (USP7) INHIBITORS AND USES THEREOF | FAXIAN THERAPEUTICS, LLC (US) | 2022-08-11 | — | — | WO | disclosed |
| CN-105189504-B | Fused tetracyclic bromodomain inhibitors | 艾伯维公司 | 2017-07-18 | — | — | CN | disclosed |
| CN-105189504-A | Fused tetracyclic bromodomain inhibitors | ABBVIE INC | 2015-12-23 | — | — | CN | disclosed |