Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 4/20 | 0.43 |
| ▸ | PIM2 | Q9P1W9 | 4/20 | 0.43 |
| ▸ | TTK | P33981 | 3/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 9/20 | 0.35 |
| ▸ | CDK2 | P24941 | 9/20 | 0.35 |
| ▸ | DUSP10 | Q9Y6W6 | 5/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.34 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.34 |
| ▸ | MAPT | P10636 | 1/20 | 0.34 |
| ▸ | NTRK1 | P04629 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL27919687 | 0.85 | SLC22A6 (0.33) | TTKCCNA2CDK2 | |
| SCHEMBL27919667 | 0.84 | MAP3K14 (0.43) | TTKCCNA2CDK2KDM4EALDH1A1 | |
| SCHEMBL12466293 | 0.80 | PIM1 (0.47) | PIM1PIM2TTKCCNA2CDK2 | |
| SCHEMBL12466564 | 0.80 | PIM1 (0.45) | PIM1PIM2TTKCCNA2CDK2 | |
| SCHEMBL12466565 | 0.79 | PIM1 (0.57) | PIM1PIM2TTKCCNA2CDK2 | |
| Hydrochloric Acid SCHEMBL28044763 | 0.71 | PIM1 (0.70) | PIM1PIM2TTKCCNA2CDK2 | |
| SCHEMBL12466369 | 0.70 | PIM1 (0.44) | PIM1PIM2TTKCCNA2CDK2 | |
| SCHEMBL9940810 | 0.70 | PIM1 (0.52) | PIM1PIM2TTKCCNA2CDK2 | |
| SCHEMBL12466433 | 0.69 | PIM1 (0.51) | PIM1PIM2TTKCCNA2CDK2 | |
| SCHEMBL12466414 | 0.68 | CCNA2 (0.46) | PIM1PIM2TTKCCNA2CDK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-103339134-B | Tricyclic pyrrolo derivatives, process for their preparation and their use as kinase inhibitors | NERVIANO MEDICAL SCIENCES S.R.L. (IT) | 2015-12-23 | — | — | CN | disclosed |