Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 4/20 | 0.44 |
| ▸ | CTSA | P10619 | 2/20 | 0.44 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.40 |
| ▸ | PDE4D | Q08499 | 2/20 | 0.39 |
| ▸ | PDE4A | P27815 | 1/20 | 0.39 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.39 |
| ▸ | FYN | P06241 | 2/20 | 0.39 |
| ▸ | FFAR4 | Q5NUL3 | 1/20 | 0.38 |
| ▸ | DHFR | P00374 | 1/20 | 0.38 |
| ▸ | NUDT1 | P36639 | 1/20 | 0.38 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.37 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.37 |
| ▸ | CCR4 | P51679 | 1/20 | 0.37 |
| ▸ | HRH1 | P35367 | 1/20 | 0.36 |
| ▸ | KDR | P35968 | 1/20 | 0.36 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.36 |
| ▸ | TEK | Q02763 | 1/20 | 0.36 |
| ▸ | MET | P08581 | 1/20 | 0.36 |
| ▸ | AXL | P30530 | 1/20 | 0.36 |
| ▸ | MERTK | Q12866 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL16045821 | 0.90 | PDE4B (0.46) | PDE4BCTSANR1I3PDE4DPDE4A | |
| SCHEMBL16112949 | 0.85 | PDE4B (0.46) | PDE4BCTSANR1I3PDE4DPDE4A | |
| SCHEMBL16114574 | 0.84 | PDE4B (0.46) | PDE4BCTSANR1I3PDE4DPDE4A | |
| SCHEMBL16114185 | 0.84 | CTSA (0.48) | PDE4BCTSANR1I3PDE4DPDE4A | |
| SCHEMBL28045842 | 0.84 | PDE4B (0.42) | PDE4BCTSADHFRNUDT1HRH1 | |
| SCHEMBL16045964 | 0.82 | PDE4B (0.44) | PDE4BCTSANR1I3PDE4DPDE4A | |
| SCHEMBL16114578 | 0.82 | PDE4B (0.44) | PDE4BCTSANR1I3PDE4DPDE4A | |
| SCHEMBL16075859 | 0.82 | CTSA (0.48) | PDE4BCTSANR1I3PDE4DPDE4A | |
| SCHEMBL16044652 | 0.81 | PDE4B (0.43) | PDE4BCTSANR1I3PDE4DPDE4A | |
| SCHEMBL16043956 | 0.81 | CTSA (0.45) | PDE4BCTSANR1I3PDE4DPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143207-A | Substituted pyridine and substituted pyrazine compounds as PDE4 inhibitors | DART NEUROSCIENCE LLC | 2015-12-09 | — | — | CN | disclosed |