Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 12/20 | 0.71 |
| ▸ | MTOR | P42345 | 9/20 | 0.71 |
| ▸ | PIK3CB | P42338 | 6/20 | 0.71 |
| ▸ | PIK3R1 | P27986 | 3/20 | 0.64 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.64 |
| ▸ | PIK3R5 | Q8WYR1 | 2/20 | 0.64 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.64 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.64 |
| ▸ | AKR1C3 | P42330 | 1/20 | 0.64 |
| ▸ | PRKDC | P78527 | 1/20 | 0.64 |
| ▸ | PIK3C3 | Q8NEB9 | 1/20 | 0.64 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.64 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL19461018 | 0.98 | PIK3CA (0.68) | PIK3CAMTORPIK3CBPIK3R1PIK3CG | |
| SCHEMBL19457616 | 0.92 | MTOR (0.60) | PIK3CAMTORPIK3CBPIK3R1PIK3CG | |
| SCHEMBL19461017 | 0.92 | PIK3CA (0.60) | PIK3CAMTORPIK3CBPIK3R1PIK3CG | |
| SCHEMBL19461003 | 0.91 | PIK3CA (0.59) | PIK3CAMTORPIK3CBPIK3R1PIK3CG | |
| SCHEMBL1311972 | 0.86 | PIK3CA (0.53) | PIK3CAMTORPIK3CBPIK3R1PIK3CG | |
| SCHEMBL10328300 | 0.84 | PIK3CA (0.61) | PIK3CAMTORPIK3CBPIK3R1PIK3CG | |
| SCHEMBL19461002 | 0.83 | PIK3CA (0.62) | PIK3CAMTORPIK3CBPIK3R1PIK3CG | |
| SCHEMBL19460990 | 0.83 | MTOR (0.50) | PIK3CAMTORPIK3CBPIK3R1PIK3CG | |
| SCHEMBL1310196 | 0.83 | PIK3CA (0.56) | PIK3CAMTORPIK3CBPIK3R1PIK3CG | |
| SCHEMBL10327728 | 0.83 | MTOR (1.00) | PIK3CAMTORPIK3CBPIK3R1PIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105541792-A | Polycyclic PI3K inhibitors | XUANZHU PHARMA CO LTD | 2016-05-04 | — | — | CN | disclosed |